publications by Joseph A. Izatt.

Papers Published

  1. Divakar Rao, K. and Choma, M.A. and Yazdanfar, S. and Rollins, A.M. and Izatt, J.A., Molecular contrast in optical coherence tomography by use of a pump-probe technique, Opt. Lett. (USA), vol. 28 no. 5 (2003), pp. 340 - 2 .
    (last updated on 2007/04/13)

    We describe a novel technique for contrast enhancement in optical coherence tomography (OCT) that makes possible molecular-specific imaging for what is believed to be the first time. A pump-probe technique is employed in which a pulsed pump laser is tuned to ground-state absorption in a molecule of interest. The location of the target molecule population is derived from the resulting transient absorption of OCT sample-arm light acting as probe light. A signal processing technique for three-dimensional localization of the transient absorption signal is described, and preliminary results exhibiting OCT contrast from methylene blue dye in multilayer and scattering phantoms are presented

    biomedical optical imaging;dyes;light scattering;medical image processing;optical pumping;optical tomography;transients;