publications by Joseph A. Izatt.


Papers Published

  1. Yang, Changhuei and Choma, Michael A. and Lamb, Laura E. and Simon, John D. and Izatt, Joseph A., Protein-based molecular contrast optical coherence tomography with phytochrome as the contrast agent, Optics Letters, vol. 29 no. 12 (2004), pp. 1396 - 1398 [OL.29.001396] .
    (last updated on 2007/04/13)

    Abstract:
    We report the use of phytochrome A (phyA), a plant protein that can reversibly switch between two states with different absorption maxima (at 660 and 730 nm), as a contrast agent for molecular contrast optical coherence tomography (MCOCT). Our MCOCT scheme builds up a difference image revealing the distribution of phyA within a target sample from pairs of consecutive OCT A-scans acquired at a probe wavelength of 750 nm, both with and without additional illumination of the target sample with 660-nm light. We demonstrate molecular imaging with this new MCOCT modality in a target sample containing a mixture of 0.2% Intralipid and 83 μM of phyA. © 2004 Optical Society of America.

    Keywords:
    Tomography;Proteins;Light absorption;Image analysis;Fluorescence;Imaging techniques;Light scattering;Quantum efficiency;Laser pulses;Titanium;Sapphire;Backscattering;Data acquisition;