publications by Joseph A. Izatt.

Papers Published

  1. Yazdanfar, S. and Rollins, A.M. and Izatt, J.A., Ultrahigh velocity resolution imaging of the microcirculation in vivo using color Doppler optical coherence tomography, Proc. SPIE - Int. Soc. Opt. Eng. (USA), vol. 4251 (2001), pp. 156 - 64 [12.427887] .
    (last updated on 2007/04/13)

    Color Doppler optical coherence tomography (CDOCT) is a method for noninvasive cross-sectional imaging of blood flow in vivo. In previous implementations, velocity estimates were obtained by measuring the frequency shift of discrete depth-resolved backscatter spectra, resulting in a velocity resolution on the order of 1 mm/s. We present a novel processing method that detects Doppler shifts calculated across sequential axial scans, enabling ultrahigh velocity resolution (~1 micron/s) flow measurement in scattering media. This method of sequential scan processing was calibrated with a moving mirror mounted on a precision motorized translator. Latex microspheres suspended in deuterium oxide were used as a highly scattering test phantom. Laminar flow profiles down to ~15 micron/s centerline velocity (0.02 cc/hr) were observed with a sensitivity of 1.2 micron/s. Finally, vessels on the order of 10 microns in diameter were imaged in living human skin, with a relative frequency sensitivity less than 4 × 10-5. To our knowledge, these results are the lowest velocities ever measured with CDOCT

    backscatter;blood flow measurement;blood vessels;Doppler measurement;haemorheology;image resolution;laminar flow;medical image processing;optical tomography;skin;