publications by Joseph A. Izatt.

Papers Published

  1. Kulkarni, M.D. and Izatt, J.A. and Kobayashi, K. and Yazdanfar, S. and Wong, R.C.K. and Sivak, M.V. and Barton, J.K. and Welch, A.J., Optical coherence tomography: a novel tool for micron-resolution biomedical diagnostics, Proceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. `Magnificent Milestones and Emerging Opportunities in Medical Engineering' (Cat. No.97CH36136), vol. vol.2 (1997), pp. 883 - 6 [IEMBS.1997.757808] .
    (last updated on 2007/04/13)

    Optical coherence tomography (OCT) is a novel method for non-invasive sub-surface imaging of biological tissue micro-structure. OCT is based on low-coherence interferometry. OCT achieves high spatial resolution (~15 μm in three dimensions) and high sensitivity (<-100 dB) in a fiber-optically integrated system which is suitable for application in minimally invasive diagnostics, including endoscopy. The authors present in vitro cross-sectional OCT images obtained non-invasively in gastrointestinal (GI) tissues to illustrate contrast between histological layers of the GI mucosa and differentiation of the mucosa from submucosa. The authors also present a novel technique, termed color Doppler OCT (CDOCT) which is an extension of OCT for performing spatially localized optical Doppler velocimetry. The authors demonstrate micron-scale resolution tomographic imaging of bi-directional blood flow in sub-surface vessels in living tissue using CDOCT. Both OCT and CDOCT have several potential medical applications

    biomedical imaging;blood flow measurement;Doppler measurement;light coherence;light interferometry;optical tomography;