Papers Published

1. Kulkarni, M.D. and Izatt, J.A. and Kobayashi, K. and Yazdanfar, S. and Wong, R.C.K. and Sivak, M.V. and Barton, J.K. and Welch, A.J., Optical coherence tomography: a novel tool for micron-resolution biomedical diagnostics, Proceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. `Magnificent Milestones and Emerging Opportunities in Medical Engineering' (Cat. No.97CH36136), vol. vol.2 (1997), pp. 883 - 6 [IEMBS.1997.757808] .
   (last updated on 2007/04/13)

   Abstract:
   Optical coherence tomography (OCT) is a novel method for non-invasive sub-surface imaging of biological tissue micro-structure. OCT is based on low-coherence interferometry. OCT achieves high spatial resolution (~15 μm in three dimensions) and high sensitivity (<-100 dB) in a fiber-optically integrated system which is suitable for application in minimally invasive diagnostics, including endoscopy. The authors present in vitro cross-sectional OCT images obtained non-invasively in gastrointestinal (GI) tissues to illustrate contrast between histological layers of the GI mucosa and differentiation of the mucosa from submucosa. The authors also present a novel technique, termed color Doppler OCT (CDOCT) which is an extension of OCT for performing spatially localized optical Doppler velocimetry. The authors demonstrate micron-scale resolution tomographic imaging of bi-directional blood flow in sub-surface vessels in living tissue using CDOCT. Both OCT and CDOCT have several potential medical applications

   Keywords:
   biomedical imaging;blood flow measurement;Doppler measurement;light coherence;light interferometry;optical tomography;