publications by Joseph A. Izatt.


Papers Published

  1. Ellerbee, A.K. and Choma, M.A. and McDowell, E.J. and Creazzo, A.L. and Izatt, J.A., Characterizing cellular contractility and cytoplasmic flow using spectral domain phase microscopy, Proc. SPIE - Int. Soc. Opt. Eng. (USA), vol. 5690 no. 1 (2005), pp. 403 - 7 [12.592809] .
    (last updated on 2007/04/13)

    Abstract:
    The phase information inherent to spectral domain optical coherence tomography (OCT) processing can be exploited to resolve sub-coherence length displacement variations. Spectral domain phase microscopy (SDPM) is a functional extension of Fourier domain OCT whose common-path topology enables extraordinary phase sensitivity. Here we demonstrate the usefulness of SDPM in three biologically relevant applications: real-time tracking of cell surface displacements of contracting cardiac myocytes, extracting cytoplasmic flow characteristics for a single-celled organism (flow rates ≈10-30μm/s), and cellular mechanical responses to cytoskeletal drug treatments. The results of these experiments are corroborated by light microscopy acquired concurrently with the SDPM data

    Keywords:
    biomechanics;biomedical optical imaging;cellular biophysics;drugs;Fourier transform optics;optical tomography;