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Bruce Klitzman, Assistant Research Professor of Surgery-Plastic Max & Oral Surgery and Biomedical Engineering  


Bruce Klitzman
Contact Info:
Office Location:  0019 Res PK IV
Email Address:   send me a message
Web Page: http://www.duke.edu/~klitz/klitzman.html

Teaching (Fall 2008):

Education:

PhD, University of Virginia, 1979
Ph.D., University of Virginia, 1979
BSE, Duke University, 1974
Specialties:

Tissue Repair, Tissue Engineering
Biological Materials
Sensing and Sensor Systems
Drug Delivery
Research Interests:

The primary basic science research interests of our laboratory are in the area of physiological mechanisms of maintaining substrate transport from blood to tissue. This broad topic covers studies on whole animals, such as rats and mice, as well as studies on whole organ, hemorheological, microvascular, cellular, ultrastructural, and molecular levels. The current projects include: 1) control of blood flow and flow distribution in the microcirculation; 2) the effects of synthetic and biologic implants on substrate transport to tissues; 3) the physiological adaptation of the microcirculation and mitochondria to chronic hypoxia, hyperoxia, or cold, and the subsequent alteration in oxygen transport; 4) mathematical modeling of tissue oxygen tension distribution and angiogenesis. 5) tissue engineering; combining isolated cells with biomaterials to form specialized composite structures for implantation, with particular emphasis on endothelial cell physiology and its alteration by isolation and seeding on biomaterials; 6) decreasing the thrombogenicity of synthetic blood vessels and improving their overall performance and biocompatibility; 7) the investigation of tissue damage resulting from abnormal perfusion (e.g., relative ischemia, anoxia, etc.) and therapies which minimize ischemic damage; 8) the abnormal development of tumor microcirculation and its effect on tumor oxygenation; 9) measurement of tissue blood flow and oxygenation as an indicator of tissue viability and functional potential; 10) development of biocompatible materials for soft tissue reconstruction or augmentation; 11) molecular and cellular effects of ultraviolet light on skin which can lead to cancer, and therapies which may minimize damage; 12) wound healing in bone and soft tissues, with special emphasis on the detection and treatment of infection and its effects on healing. 13) improving the outflow facility of ophthalmologic devices implanted to reduce elevated intraocular pressures found in patients with glaucoma. Future studies will continue to focus on improving the biocompatibility of biosynthetic implants. Additional new emphasis may be placed on investigating the effects of radiation on wound healing and methods of minimizing the consequences of radiation exposure. Specific collaborations with faculty in Biomedical Engineering include improving the biocompatibility of biosensors, surface modification of implanted devices, and transplanting endothelial cells onto small diameter synthetic vascular grafts.

Current Ph.D. Students  

  • Heather L Prichard  
Representative Publications   (More Publications)

  1. SJ Kovach, KE Koger, B Klitzman, G Germann, LS Levin, Advantages of minimally invasive, balloon-dissector-assisted tissue expander placement: a clinical and experimental study., Annals of plastic surgery, United States, vol. 60 no. 1 (January, 2008), pp. 89-97  [abs].
  2. J Lanzen, RD Braun, B Klitzman, D Brizel, TW Secomb, MW Dewhirst, Direct demonstration of instabilities in oxygen concentrations within the extravascular compartment of an experimental tumor., Cancer research, United States, vol. 66 no. 4 (February, 2006), pp. 2219-23  [abs].
  3. HL Prichard, W Reichert, B Klitzman, IFATS Series: Adipose-Derived Stromal Cells Improve The Foreign Body Response., Stem cells (Dayton, Ohio) (April, 2008)  [abs].
  4. KC Olbrich, R Meade, W Bruno, L Heller, B Klitzman, LS Levin, Halofuginone inhibits collagen deposition in fibrous capsules around implants., Annals of plastic surgery, United States, vol. 54 no. 3 (March, 2005), pp. 293-6;discussion 296  [abs].
  5. HE Koschwanez, FY Yap, B Klitzman, WM Reichert, In vitro and in vivo characterization of porous poly-L-lactic acid coatings for subcutaneously implanted glucose sensors., Journal of biomedical materials research. Part A (January, 2008)  [abs].
  6. BP Chan, W Liu, B Klitzman, WM Reichert, GA Truskey, In vivo performance of dual ligand augmented endothelialized expanded polytetrafluoroethylene vascular grafts., Journal of biomedical materials research. Part B, Applied biomaterials, United States, vol. 72 no. 1 (January, 2005), pp. 52-63  [abs].
  7. HL Prichard, WM Reichert, B Klitzman, Adult adipose-derived stem cell attachment to biomaterials., Biomaterials, England, vol. 28 no. 6 (February, 2007), pp. 936-46  [abs].
  8. BJ Nablo, HL Prichard, RD Butler, B Klitzman, MH Schoenfisch, Inhibition of implant-associated infections via nitric oxide release., Biomaterials, England, vol. 26 no. 34 (December, 2005), pp. 6984-90  [abs].
  9. KE Follmar, HL Prichard, FC DeCroos, HT Wang, LS Levin, B Klitzman, KC Olbrich, D Erdmann, Combined bone allograft and adipose-derived stem cell autograft in a rabbit model., Annals of plastic surgery, United States, vol. 58 no. 5 (May, 2007), pp. 561-5  [abs].
  10. J Ko, J Ross, H Awad, H Hurwitz, B Klitzman, The effects of ZD6474, an inhibitor of VEGF signaling, on cutaneous wound healing in mice., The Journal of surgical research, United States, vol. 129 no. 2 (December, 2005), pp. 251-9  [abs].
  11. A Baccarani, K Yasui, KC Olbrich, A El-Sabbagh, S Kovach, KE Follmar, D Erdmann, LS Levin, JS Stamler, B Klitzman, MR Zenn, Efficacy of ethyl nitrite in reversing surgical vasospasm., Journal of reconstructive microsurgery, United States, vol. 23 no. 5 (July, 2007), pp. 257-62  [abs].
  12. MS Wong, D Erdmann, R Sweis, C Pöllmann, M Farrar, GS Georgiade, LS Levin, KC Olbrich, B Klitzman, Basic fibroblast growth factor expression following surgical delay of rat transverse rectus abdominis myocutaneous flaps., Plastic and reconstructive surgery, United States, vol. 113 no. 7 (June, 2004), pp. 2030-6  [abs].
  13. EM Hetrick, HL Prichard, B Klitzman, MH Schoenfisch, Reduced foreign body response at nitric oxide-releasing subcutaneous implants., Biomaterials, England, vol. 28 no. 31 (November, 2007), pp. 4571-80  [abs].
  14. Q Dai, J Huang, B Klitzman, C Dong, PJ Goldschmidt-Clermont, KL March, J Rokovich, B Johnstone, EJ Rebar, SK Spratt, CC Case, CD Kontos, BH Annex, Engineered zinc finger-activating vascular endothelial growth factor transcription factor plasmid DNA induces therapeutic angiogenesis in rabbits with hindlimb ischemia., Circulation, United States, vol. 110 no. 16 (October, 2004), pp. 2467-75  [abs].
  15. LW Norton, HE Koschwanez, NA Wisniewski, B Klitzman, WM Reichert, Vascular endothelial growth factor and dexamethasone release from nonfouling sensor coatings affect the foreign body response., Journal of biomedical materials research. Part A, United States, vol. 81 no. 4 (June, 2007), pp. 858-69  [abs].
  16. D Erdmann, AM Pippen, KJ Moquin, R Sweis, LE Niklason, LS Levin, KC Olbrich, B Klitzman, Immunohistochemical identification of vascular endothelial growth factor in pig latissimus dorsi musculocutaneous flaps following ischemia-reperfusion injury., Annals of plastic surgery, United States, vol. 53 no. 4 (October, 2004), pp. 398-403  [abs].
  17. C Heitmann, FN Khan, D Erdmann, KC Olbrich, A Adam Sharkawy, B Klitzman, Vein graft anastomoses with magnets., Journal of plastic, reconstructive & aesthetic surgery : JPRAS, Netherlands, vol. 60 no. 12 (2007), pp. 1296-301  [abs].
  18. D Erdmann, R Sweis, C Heitmann, K Yasui, KC Olbrich, LS Levin, AA Sharkawy, B Klitzman, Side-to-side sutureless vascular anastomosis with magnets., Journal of vascular surgery : official publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter, United States, vol. 40 no. 3 (September, 2004), pp. 505-11  [abs].
  19. AC Lockhart, RD Braun, D Yu, JR Ross, MW Dewhirst, JS Humphrey, S Thompson, KM Williams, B Klitzman, F Yuan, JM Grichnik, AD Proia, DA Conway, HI Hurwitz, Reduction of wound angiogenesis in patients treated with BMS-275291, a broad spectrum matrix metalloproteinase inhibitor., Clinical cancer research : an official journal of the American Association for Cancer Research, United States, vol. 9 no. 2 (February, 2003), pp. 586-93  [abs].
  20. YB Kim, HP Reisch, D Serafin, B Klitzman, Evaluation of the thrombogenecity of microvascular prosthesis by in vivo microscopy., Journal of Korean medical science, KOREA, vol. 9 no. 5 (October, 1994), pp. 357-61  [abs].
  21. D Erdmann, R Sweis, MS Wong, LE Niklason, TV du Laney, LS Levin, B Klitzman, KC Olbrich, Vascular endothelial growth factor expression in pig latissimus dorsi myocutaneous flaps after ischemia reperfusion injury., Plastic and reconstructive surgery, United States, vol. 111 no. 2 (February, 2003), pp. 775-80  [abs].
  22. N Wisniewski, N Rajamand, U Adamsson, PE Lins, WM Reichert, B Klitzman, U Ungerstedt, Analyte flux through chronically implanted subcutaneous polyamide membranes differs in humans and rats., American journal of physiology. Endocrinology and metabolism, United States, vol. 282 no. 6 (June, 2002), pp. E1316-23  [abs].
  23. JA Stenken, WM Reichert, B Klitzman, Magnetic resonance imaging of a tissue/implanted device biointerface using in vivo microdialysis sampling., Analytical chemistry, United States, vol. 74 no. 18 (September, 2002), pp. 4849-54  [abs].
  24. D Erdmann, R Sweis, MS Wong, CE Eyler, KC Olbrich, LS Levin, G Germann, B Klitzman, [Current perspectives of orthogonal polarization spectral imaging in plastic surgery], Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen, Germany, vol. 73 no. 8 (August, 2002), pp. 827-32  [abs].
  25. N Wisniewski, B Klitzman, B Miller, WM Reichert, Decreased analyte transport through implanted membranes: differentiation of biofouling from tissue effects., Journal of biomedical materials research, United States, vol. 57 no. 4 (December, 2001), pp. 513-21  [abs].
  26. L Heller, LS Levin, B Klitzman, Laser Doppler flowmeter monitoring of free-tissue transfers: blood flow in normal and complicated cases., Plastic and reconstructive surgery, United States, vol. 107 no. 7 (June, 2001), pp. 1739-45  [abs].
  27. AG Ravin, KC Olbrich, LS Levin, AL Usala, B Klitzman, Long- and short-term effects of biological hydrogels on capsule microvascular density around implants in rats., Journal of biomedical materials research, United States, vol. 58 no. 3 (May, 2001), pp. 313-8  [abs].
  28. SN Ettinger, CC Poellmann, NA Wisniewski, AA Gaskin, JS Shoemaker, JM Poulson, MW Dewhirst, B Klitzman, Urea as a recovery marker for quantitative assessment of tumor interstitial solutes with microdialysis., Cancer research, United States, vol. 61 no. 21 (November, 2001), pp. 7964-70  [abs].
  29. Klitzman B., R.D. Braun, A.C. Lockhart, L. Heller, M.W. Dewhirst, and H.I. Hurwitz.  Wound-induced angiogenesis: A clinical model.  Prog Appl Microcirc 24:11-15, 2000 .
  30. MW Dewhirst, B Klitzman, RD Braun, DM Brizel, ZA Haroon, TW Secomb, Review of methods used to study oxygen transport at the microcirculatory level., International journal of cancer. Journal international du cancer, UNITED STATES, vol. 90 no. 5 (October, 2000), pp. 237-55  [abs].
  31. SA Brown, AJ Mayberry, JA Mathy, TM Phillips, B Klitzman, LS Levin, The effect of muscle flap transposition to the fracture site on TNFalpha levels during fracture healing., Plastic and reconstructive surgery, UNITED STATES, vol. 105 no. 3 (March, 2000), pp. 991-8  [abs].
  32. BM Sundin, MA Hussein, S Glasofer, MH El-Falaky, SM Abdel-Aleem, RE Sachse, B Klitzman, The role of allopurinol and deferoxamine in preventing pressure ulcers in pigs., Plastic and reconstructive surgery, UNITED STATES, vol. 105 no. 4 (April, 2000), pp. 1408-21  [abs].
  33. MW Dewhirst, ET Ong, RD Braun, B Smith, B Klitzman, SM Evans, D Wilson, Quantification of longitudinal tissue pO2 gradients in window chamber tumours: impact on tumour hypoxia., British journal of cancer, SCOTLAND, vol. 79 no. 11-12 (April, 1999), pp. 1717-22  [abs].
  34. RE Sachse, SA Fink, B Klitzman, Comparison of supine and lateral positioning on various clinically used support surfaces., Annals of plastic surgery, UNITED STATES, vol. 41 no. 5 (November, 1998), pp. 513-8  [abs].
  35. AA Sharkawy, B Klitzman, GA Truskey, WM Reichert, Engineering the tissue which encapsulates subcutaneous implants. II. Plasma-tissue exchange properties., Journal of biomedical materials research, UNITED STATES, vol. 40 no. 4 (June, 1998), pp. 586-97  [abs].
  36. AA Sharkawy, B Klitzman, GA Truskey, WM Reichert, Engineering the tissue which encapsulates subcutaneous implants. III. Effective tissue response times., Journal of biomedical materials research, UNITED STATES, vol. 40 no. 4 (June, 1998), pp. 598-605  [abs].
  37. EF Ritter, MM Fata, AM Rudner, B Klitzman, Heparin bonding increases patency of long microvascular prostheses., Plastic and reconstructive surgery, UNITED STATES, vol. 101 no. 1 (January, 1998), pp. 142-6  [abs].
  38. EF Ritter, JC Cronan, AM Rudner, D Serafin, B Klitzman, Improved microsurgical anastomotic patency with low molecular weight heparin., Journal of reconstructive microsurgery, UNITED STATES, vol. 14 no. 5 (July, 1998), pp. 331-6  [abs].
  39. VD Bhat, B Klitzman, K Koger, GA Truskey, WM Reichert, Improving endothelial cell adhesion to vascular graft surfaces: clinical need and strategies., Journal of biomaterials science. Polymer edition, NETHERLANDS, vol. 9 no. 11 (1998), pp. 1117-35  [abs].
  40. RE Sachse, SA Fink, B Klitzman, Multimodality evaluation of pressure relief surfaces., Plastic and reconstructive surgery, UNITED STATES, vol. 102 no. 7 (December, 1998), pp. 2381-7  [abs].
  41. B Klitzman, C Kalinowski, SL Glasofer, L Rugani, Pressure ulcers and pressure relief surfaces., Clinics in plastic surgery, UNITED STATES, vol. 25 no. 3 (July, 1998), pp. 443-50  [abs].
  42. ML Maynor, RE Moon, B Klitzman, PJ Fracica, A Canada, Brown recluse spider envenomation: a prospective trial of hyperbaric oxygen therapy., Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, UNITED STATES, vol. 4 no. 3 (March, 1997), pp. 184-92  [abs].
  43. AA Sharkawy, B Klitzman, GA Truskey, WM Reichert, Engineering the tissue which encapsulates subcutaneous implants. I. Diffusion properties., Journal of biomedical materials research, UNITED STATES, vol. 37 no. 3 (December, 1997), pp. 401-12  [abs].
  44. EF Ritter, YB Kim, HP Reischl, D Serafin, AM Rudner, B Klitzman, Heparin coating of vascular prostheses reduces thromboemboli., Surgery, UNITED STATES, vol. 122 no. 5 (November, 1997), pp. 888-92  [abs].
  45. PJ Viscardi, EA Page, HG Clark, D Serafin, B Klitzman, Iloprost in alginate decreases the thrombogenicity of expanded polytetrafluoroethylene., Journal of reconstructive microsurgery, UNITED STATES, vol. 13 no. 4 (May, 1997), pp. 303-6  [abs].
  46. JM Musselwhite, B Klitzman, W Maixner, EJ Burkes, Laser Doppler flowmetry: a clinical test of pulpal vitality., Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, UNITED STATES, vol. 84 no. 4 (October, 1997), pp. 411-9  [abs].
  47. EF Ritter, M Axelrod, KW Minn, E Eades, AM Rudner, D Serafin, B Klitzman, Modulation of ultraviolet light-induced epidermal damage: beneficial effects of tocopherol., Plastic and reconstructive surgery, UNITED STATES, vol. 100 no. 4 (September, 1997), pp. 973-80  [abs].
  48. G Zavitsanos, L Huang, W Panza, D Serafin, B Klitzman, Limiting impairment of muscle function following ischemia and reperfusion in rabbits., Journal of reconstructive microsurgery, UNITED STATES, vol. 12 no. 3 (April, 1996), pp. 183-7  [abs].
  49. EF Ritter, JP Anthony, LS Levin, CP Demas, B Klitzman, D Skarada, D Serafin, Microsurgical composite tissue transplantation at difficult recipient sites facilitated by preliminary installation of vein grafts as arteriovenous loops., Journal of reconstructive microsurgery, UNITED STATES, vol. 12 no. 4 (May, 1996), pp. 231-40  [abs].
  50. KD Sonntag, B Klitzman, EJ Burkes, J Hoke, J Moshonov, Pulpal response to cavity preparation with the Er:YAG and Mark III free electron lasers., Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, UNITED STATES, vol. 81 no. 6 (June, 1996), pp. 695-702  [abs].
  51. 2. Kimura, H., N.Z. Wu, R. Dodge, D.P. Spencer, B. Klitzman, T.M. McIntyre, and M.W. Dewhirst. Inhibition of radiation-induced up-regulation of leukocyte adhesion to endothelial cells with the platelet-activating factor inhibitor, BN52021. Int. J. Rad. Onc., Biol., Phys. 33:627-633, 1995. .
  52. DJ Skarada, GR Erickson, KL Warnecke, TV du Laney, CS Greenberg, EF Ritter, B Klitzman, Assessments of thrombogenicity by three in vitro techniques. Student Research Award in the Undergraduate, Master Candidate, or Health Science Degree Candidate Category, 21st annual meeting of the Society for Biomaterials, San Francisco, CA, March 18-22, 1995., Journal of biomedical materials research, UNITED STATES, vol. 29 no. 9 (September, 1995), pp. 1039-45  [abs].
  53. J Zhang, AD Sam, B Klitzman, CA Piantadosi, Inhibition of nitric oxide synthase on brain oxygenation in anesthetized rats exposed to hyperbaric oxygen., Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc, UNITED STATES, vol. 22 no. 4 (December, 1995), pp. 377-82  [abs].
  54. H Kimura, NZ Wu, R Dodge, DP Spencer, BM Klitzman, TM McIntyre, MW Dewhirst, Inhibition of radiation-induced up-regulation of leukocyte adhesion to endothelial cells with the platelet-activating factor inhibitor, BN52021., International journal of radiation oncology, biology, physics, UNITED STATES, vol. 33 no. 3 (October, 1995), pp. 627-33  [abs].
  55. J Zhang, H Benveniste, B Klitzman, CA Piantadosi, Nitric oxide synthase inhibition and extracellular glutamate concentration after cerebral ischemia/reperfusion., Stroke; a journal of cerebral circulation, UNITED STATES, vol. 26 no. 2 (February, 1995), pp. 298-304  [abs].
  56. JA Hoke, EJ Burkes, JT White, MB Duffy, B Klitzman, Blood-flow mapping of oral tissues by laser Doppler flowmetry., International journal of oral and maxillofacial surgery, DENMARK, vol. 23 no. 5 (October, 1994), pp. 312-5  [abs].
  57. NZ Wu, BA Ross, C Gulledge, B Klitzman, R Dodge, MW Dewhirst, Differences in leucocyte-endothelium interactions between normal and adenocarcinoma bearing tissues in response to radiation., British journal of cancer, SCOTLAND, vol. 69 no. 5 (May, 1994), pp. 883-9  [abs].
  58. Problems in General Surgery: Biomaterials. ed. B. Klitzman. Lippincott, 1994. .
  59. B Klitzman, Rheology and the regulation of oxygen delivery., Microsurgery, UNITED STATES, vol. 15 no. 6 (1994), pp. 369-73 .
  60. Sepka, R., D. Serafin, and B. Klitzman. Plastic Surgery: Routine clinical use of laser Doppler to monitor free tissue transfer. in Laser Doppler Flowmeter Applications. ed. G.V. Belcaro, U. Hoffman, A. Bollinger, and A. Nicolaides. Med-Orion. London, 1994. .
  61. Yuen, J., B. Klitzman, and D. Serafin. Biomaterials in Plastic Surgery. in Implantation Biology: The Host Response and Biomedical Devices. ed. R. Greco. CRC Press, 1993. .
  62. DM Brizel, B Klitzman, JM Cook, J Edwards, G Rosner, MW Dewhirst, A comparison of tumor and normal tissue microvascular hematocrits and red cell fluxes in a rat window chamber model., International journal of radiation oncology, biology, physics, UNITED STATES, vol. 25 no. 2 (January, 1993), pp. 269-76  [abs].
  63. TW Secomb, R Hsu, MW Dewhirst, B Klitzman, JF Gross, Analysis of oxygen transport to tumor tissue by microvascular networks., International journal of radiation oncology, biology, physics, UNITED STATES, vol. 25 no. 3 (February, 1993), pp. 481-9  [abs].
  64. DS Peterseim, CH Meyers, DM Craig, JS Heinle, AM Jayawant, JJ Devaney, BM Klitzman, P Van Trigt, Enhanced cardiac preservation with oxygenated University of Wisconsin solution., The Journal of surgical research, UNITED STATES, vol. 55 no. 6 (December, 1993), pp. 588-94  [abs].
  65. NZ Wu, B Klitzman, G Rosner, D Needham, MW Dewhirst, Measurement of material extravasation in microvascular networks using fluorescence video-microscopy., Microvascular research, UNITED STATES, vol. 46 no. 2 (September, 1993), pp. 231-53  [abs].
  66. RD Vann, EF Ritter, MD Plunkett, CW Wyble, CV Bensen, WA Gerth, WJ Barwick, B Klitzman, Patency and blood flow in gas denucleated arterial prostheses., Journal of biomedical materials research, UNITED STATES, vol. 27 no. 4 (April, 1993), pp. 493-8  [abs].
  67. MD Wigod, B Klitzman, Quantification of in vitro endothelial cell adhesion to vascular graft material., Journal of biomedical materials research, UNITED STATES, vol. 27 no. 8 (August, 1993), pp. 1057-62  [abs].
  68. DL Feldman, RS Sepka, B Klitzman, Tissue oxygenation and blood flow on specialized and conventional hospital beds., Annals of plastic surgery, UNITED STATES, vol. 30 no. 5 (May, 1993), pp. 441-4  [abs].
  69. NZ Wu, B Klitzman, R Dodge, MW Dewhirst, Diminished leukocyte-endothelium interaction in tumor microvessels., Cancer research, UNITED STATES, vol. 52 no. 15 (August, 1992), pp. 4265-8  [abs].
  70. MW Dewhirst, RZ Vinuya, ET Ong, B Klitzman, G Rosner, TW Secomb, JF Gross, Effects of bradykinin on the hemodynamics of tumor and granulating normal tissue microvasculature., Radiation research, UNITED STATES, vol. 130 no. 3 (June, 1992), pp. 345-54  [abs].
  71. AJ Fisher, NW Schrader, B Klitzman, Effects of chronic hypoxia on capillary flow and hematocrit in rat skeletal muscle., The American journal of physiology, UNITED STATES, vol. 262 no. 6 Pt 2 (June, 1992), pp. H1877-83  [abs].
  72. MW Dewhirst, ET Ong, D Madwed, B Klitzman, T Secomb, D Brizel, J Bonaventura, G Rosner, B Kavanagh, J Edwards, Effects of the calcium channel blocker flunarizine on the hemodynamics and oxygenation of tumor microvasculature., Radiation research, UNITED STATES, vol. 132 no. 1 (October, 1992), pp. 61-8  [abs].
  73. MW Dewhirst, ET Ong, B Klitzman, TW Secomb, RZ Vinuya, R Dodge, D Brizel, JF Gross, Perivascular oxygen tensions in a transplantable mammary tumor growing in a dorsal flap window chamber., Radiation research, UNITED STATES, vol. 130 no. 2 (May, 1992), pp. 171-82  [abs].
  74. MS Clinton, RS Sepka, D Bristol, WC Pederson, WJ Barwick, D Serafin, B Klitzman, Establishment of normal ranges of laser Doppler blood flow in autologous tissue transplants., Plastic and reconstructive surgery, UNITED STATES, vol. 87 no. 2 (February, 1991), pp. 299-309  [abs].
  75. CV Bensen, RD Vann, KE Koger, B Klitzman, Quantification of gas denucleation and thrombogenicity of vascular grafts., Journal of biomedical materials research, UNITED STATES, vol. 25 no. 3 (March, 1991), pp. 373-86  [abs].
  76. KW Minn, D Serafin, E Mikat, B Klitzman, Reconstruction of rat femoral veins with microvascular prostheses., Plastic and reconstructive surgery, UNITED STATES, vol. 87 no. 3 (March, 1991), pp. 536-42  [abs].
  77. BP Perona, JV Bartolome, RS Sepka, D Serafin, B Klitzman, Acute difluoromethylornithine treatment increases skin flap survival in rats., Annals of plastic surgery, UNITED STATES, vol. 25 no. 1 (July, 1990), pp. 26-8  [abs].
  78. J Goldberg, RS Sepka, BP Perona, WC Pederson, B Klitzman, Laser Doppler blood flow measurements of common cutaneous donor sites for reconstructive surgery., Plastic and reconstructive surgery, UNITED STATES, vol. 85 no. 4 (April, 1990), pp. 581-6  [abs].
  79. M Goldberg, D Serafin, B Klitzman, Quantification of neutrophil adhesion to skeletal muscle venules following ischemia-reperfusion., Journal of reconstructive microsurgery, UNITED STATES, vol. 6 no. 3 (July, 1990), pp. 267-70  [abs].
  80. WG Eshbaugh, BG Forley, EF Ritter, D Serafin, B Klitzman, Stimulation of DNA synthesis in human epidermis by UVB radiation and its inhibition by difluoromethylornithine., Plastic and reconstructive surgery, UNITED STATES, vol. 85 no. 4 (April, 1990), pp. 593-6  [abs].
  81. RW Burk, D Serafin, B Klitzman, Toxic effects of catecholamines on skin., Plastic and reconstructive surgery, UNITED STATES, vol. 85 no. 1 (January, 1990), pp. 92-9  [abs].
  82. M Axelrod, D Serafin, B Klitzman, Ultraviolet light and free radicals: an immunologic theory of epidermal carcinogenesis., Plastic and reconstructive surgery, UNITED STATES, vol. 86 no. 3 (September, 1990), pp. 582-93 .
  83. EF Ritter, RD Vann, C Wyble, WJ Barwick, B Klitzman, Hydrostatic pressure reduces thrombogenicity of polytetrafluoroethylene vascular grafts., The American journal of physiology, UNITED STATES, vol. 257 no. 4 Pt 2 (October, 1989), pp. H1076-81  [abs].
  84. YR Smith, B Klitzman, MN Ellis, FC Kull, The effect of nicotinamide on microvascular density and thermal injury in rats., The Journal of surgical research, UNITED STATES, vol. 47 no. 5 (November, 1989), pp. 465-9  [abs].
  85. CP Demas, R Vann, E Ritter, RS Sepka, B Klitzman, WJ Barwick, Decreased thrombogenicity of vascular prostheses following gas denucleation by hydrostatic pressure., Plastic and reconstructive surgery, UNITED STATES, vol. 82 no. 6 (December, 1988), pp. 1042-5  [abs].
  86. L Huang, CT Privalle, D Serafin, B Klitzman, Increased survival of skin flaps by scavengers of superoxide radical., The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, UNITED STATES, vol. 1 no. 2 (August, 1987), pp. 129-32  [abs].
  87. B Klitzman, Microvascular determinants of blood flow., Journal of reconstructive microsurgery, UNITED STATES, vol. 4 no. 1 (October, 1987), pp. 77-80 .
  88. J Gelman, JV Bartolome, S Jenkins, D Serafin, SM Schanberg, B Klitzman, Reduced cell death in skin flaps in rats treated with difluoromethylornithine., The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, UNITED STATES, vol. 1 no. 6 (December, 1987), pp. 474-7  [abs].
  89. SD Jenkins, RS Sepka, WJ Barwick, D Serafin, B Klitzman, Routine clinical use of laser Doppler flowmeter to monitor free tissue transfer: preliminary results., Journal of reconstructive microsurgery, UNITED STATES, vol. 3 no. 4 (July, 1987), pp. 281-3  [abs].
  90. BP Fleming, B Klitzman, WO Johnson, Measurement of erythrocyte velocity by use of a periodic differential detector., The American journal of physiology, UNITED STATES, vol. 249 no. 4 Pt 2 (October, 1985), pp. H899-905  [abs].
  91. B Klitzman, SJ Fronczak, Mitochondrial distribution in hamster cremaster muscle., Advances in experimental medicine and biology, UNITED STATES, vol. 180 (1984), pp. 695-700 .
  92. B Klitzman, AS Popel, BR Duling, Oxygen transport in resting and contracting hamster cremaster muscles: experimental and theoretical microvascular studies., Microvascular research, UNITED STATES, vol. 25 no. 1 (January, 1983), pp. 108-31  [abs].
  93. B Klitzman, DN Damon, RJ Gorczynski, BR Duling, Augmented tissue oxygen supply during striated muscle contraction in the hamster. Relative contributions of capillary recruitment, functional dilation, and reduced tissue PO2., Circulation research, UNITED STATES, vol. 51 no. 6 (December, 1982), pp. 711-21  [abs].
  94. B Klitzman, PC Johnson, Capillary network geometry and red cell distribution in hamster cremaster muscle., The American journal of physiology, UNITED STATES, vol. 242 no. 2 (February, 1982), pp. H211-9  [abs].
  95. BR Duling, B Klitzman, Local control of microvascular function: role in tissue oxygen supply., Annual review of physiology, UNITED STATES, vol. 42 (1980), pp. 373-82 .
  96. B Klitzman, BR Duling, Microvascular hematocrit and red cell flow in resting and contracting striated muscle., The American journal of physiology, UNITED STATES, vol. 237 no. 4 (October, 1979), pp. H481-90  [abs].
  97. RJ Gorczynski, B Klitzman, BR Duling, Interrelations between contracting striated muscle and precapillary microvessels., The American journal of physiology, UNITED STATES, vol. 235 no. 5 (November, 1978), pp. H494-504  [abs].
  98. AC Lockhart, RD Braun, D Yu, JR Ross, MW Dewhirst, B Klitzman, F Yuan, JM Grichnik, AD Proia, DA Conway, G Mann, HI Hurwitz, A clinical model of dermal wound angiogenesis., Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, United States, vol. 11 no. 4 , pp. 306-13  [abs].
  99. BS Sorg, CD Peltz, B Klitzman, MW Dewhirst, Method for improved accuracy in endogenous urea recovery marker calibrations for microdialysis in tumors., Journal of pharmacological and toxicological methods, United States, vol. 52 no. 3 , pp. 341-9  [abs].
Biomedical Engineering Department
Pratt School of Engineering | Duke University
Room 136 Hudson Hall • Box 90281 • Durham, NC 27708-0281
Phone: (919) 660-5131 • Fax: (919) 684-4488