Papers Published

1. Barr, R.C. and Plonsey, R., Electrophysiological interaction through the interstitial space between adjacent unmyelinated parallel fibers, Biophys. J. (USA), vol. 61 no. 5 (1992), pp. 1164 - 75 .
   (last updated on 2007/04/12)

   Abstract:
   The influence of interstitial or extracellular potentials on propagation usually has been ignored, often through assuming these potentials to be insignificantly different from zero, presumably because both measurements and calculations become much more complex when interstitial interactions are included. The study arose primarily from an interest in cardiac muscle, where it has been well established that substantial interstitial potentials occur in tightly packed structures, e.g., tens of millivolts within the ventricular wall. The authors analyzed the electrophysiological interaction between two adjacent unmyelinated fibers within a restricted extracellular space. Numerical evaluations made use of two linked core-conductor models and Hodgkin-Huxley membrane properties. Changes in transmembrane potentials induced in the second fiber ranged from nonexistent with large intervening volumes to large enough to initiate excitation when fibers were coupled by interstitial currents through a small interstitial space

   Keywords:
   bioelectric potentials;muscle;