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Sidney A Simon, Professor of Neurobiology, Department of Anesthesiology and Biomedical Engineering  


Sidney A Simon
Contact Info:
Office Location:  327C Bryan Res Bldg
Email Address:   send me a message
Web Page: http://neurobiology.mc.duke.edu/Faculty/simon/

Education:

Ph.D., Northwestern University, 1973
Specialties:

Polymer and Protein Engineering
Neural Prosthesis
Representative Publications   (More Publications)

  1. W Liedtke, SA Simon, A possible role for TRPV4 receptors in asthma., American journal of physiology. Lung cellular and molecular physiology, United States, vol. 287 no. 2 (August, 2004), pp. L269-71 .
  2. Allende, D., S. A. Simon  and T. J. McIntosh (2004) Melittin-Induced Bilayer Leakage Depends on Curvature –Elastic Energy: Evidence for a toroidal pore. Biophysical Journal (in press). .
  3. L Liu, T Yang, SA Simon, The protein tyrosine kinase inhibitor, genistein, decreases excitability of nociceptive neurons., Pain, Netherlands, vol. 112 no. 1-2 (November, 2004), pp. 131-41  [abs].
  4. Costa, R. M., L. Liu,  M. A. L. N. Nicolelis and S.A. Simon (2004)  Gustatory effects of capsaicin  that are independent of TRPV1 receptors. Chem. Senses (In Press). .
  5. L Liu, T Yang, MJ Bruno, OS Andersen, SA Simon, Voltage-gated ion channels in nociceptors: modulation by cGMP., Journal of neurophysiology, United States, vol. 92 no. 4 (October, 2004), pp. 2323-32  [abs].
  6. Lu, G., D. Henderson, L. Liu, S. A. Simon and P. Reinhart (2004) Cloning and functional characterization of TRPV1b, a new human vanilloid receptor. Molecular Pharmacology (submitted). .
  7. Soares, E. and S. A. Simon (2004) Chemical tuning changes in gustatory cortical neurons in awake rats(submitted for publication. .
  8. Agopyan, N. Bhatti, T. Yu, S and S. A. Simon  (2003) Vanilloid receptor activation by 2 and 10 m particles induce apoptosis in human lung cells. Toxicology and Applied Pharmacology 192: 21-35. .
  9. Wiest, M. C.,  E. Soares,  S. A.  Simon  and  M. A. L. N. Nicolelis (2004) Stimulus-related desynchronization of bilateral  7-12 Hz oscillations in gustatory cortex of awake rats (submitted for publication). .
  10. Liu, L., and S. A. Simon (2003) Modulation of IA Currents by capsaicin in rat trigeminal ganglion neurons. J. Neurophysiol. 89:1387-1401. .
  11. McIntosh, T. J.  Vidal, A.  and Simon, S. A.  (2003)  Sorting of Lipids and Transmembrane Peptides Between Detergent Soluble Bilayers and Detergent Resistant Rafts. Biophysical Journal 85: 1656-1666. .
  12. Agopyan, N., L. Li, S. Yu and S. A. Simon (2003) Negatively charged 2 and 10 mm particles activate vanilloid receptors, cAMP and induce IL-6 release. Toxicology and Applied Pharmacology 186: 63-76. .
  13. Allende, D.,  A. Vidal, S. A. Simon and  T. J. McIntosh (2003)  Bilayers interfacial  properties modulate the binding of amphipathic peptides. Chem. Phys. Lipids 122:65-76. .
  14. Katz, D.B., M.A.L. Nicolelis and S.A. Simon (2002) Gustatory coding is dynamic and distributed. Curr. Opin. in Neurosci. 12:448-454. .
  15. Simon, S. A., L. Liu and R. P. Erickson (2003) Neuropeptides modulate chorda tympani responses in a tastant specific manner. Am. J. Physiol.284: R1494-R1505. .
  16. Spray, D.S. and S. A. Simon (2003) “Thermoreceptors” in Encyclopedia of Neurosicience. .
  17. Gandhavadi, M., D. Allende, A. Vidal,  S. A. Simon and  T. J. McIntosh (2002) Structure, composition, and peptide binding properties of detergent soluble bilayers and detergent resistant rafts. Biophys. J. 82: 1469-1482. .
  18. Katz, D. B., S. A. Simon and M. A. L .Nicolelis (2002)  Taste specific neuronal ensembles from the gustatory cortex of awake rats. J. Neurosci. 22: 1890-1857. .
  19. Liu, L.,  L. Li  and S. A .Simon (2003) Modulation of TTX-resistant sodium currents by capsaicin, cAMP, cGMP and PKC in rat trigeminal ganglion neurons. J. Neurophysiology (in re-review). .
  20. McIntosh, T. J. and S. A Simon (2002) The Energetics of Peptide-Lipid Interactions: Modulation by Interfacial Dipoles and Cholesterol. In Peptide -Lipid interactions. Ed. Simon, S. A. and McIntosh, T. J. Academic Press, San Diego, Chapter 11, pp. 309-338. .
  21. Jones, S., H. Lo and S.A. Simon (2001) Nicotinic receptors in the periphery. In: Nicotinic Receptors in the Nervous System (Methods and New Frontiers in Neuroscience Series, M.A.L. Nicolelis and S.A. Simon, eds). CRC Press, pp. 79-107. .
  22. Katz, D. B., S. A. Simon and M. A. L. Nicolelis (2001) Dynamic and multimodal responses of gustatory cortical neurons in awake rats.  J. Neurosci. 21: 4478-4489. .
  23. Katz, D.B., S.A. Simon and M.A.L. Nicolelis (2001) Electrophysiological studies of gustation in awake rats. In: Methods in Chemosensory Research (Methods and New Frontiers in Neuroscience Series, M.A.L. Nicolelis and S.A. Simon, eds). CRS Press, pp. 339-357. .
  24. Liu, L. and S.A. Simon (2001) Acidic stimuli activates two distinct pathways in taste receptor cells from rat fungiform papillae. Brain Res. 923: 58-70. .
  25. Liu, L., M. Oortgiesen, L. Li and S. A. Simon (2001) Capsaicin inhibits activation of voltage-gated sodium currents in capsaicin-sensitive trigeminal ganglion neurons.  J. Neurophysiol. 85: 745-758. .
  26. McIntosh, T.J., A. Vidal and S.A. Simon (2001) The energetics of binding of a signal peptide to lipid bilayers: the role of bilayer properties. Biochem. Soc. Trans. 29: 594-598. .
  27. Oliveria, L.M., D.B. Katz, S.A. Simon and M.A.L. Nicolelis (2001) Temporal aspects of gustatory coding obtained from cortical ensembles in awake rats. Soc. Neurosci. Abstr. 27. .
  28. Eichenbaum, G.M., P.F. Kiser, D. Shah, W.P. Meuer, D. Needham and S.A. Simon (2000) Alkaline metal binding properties of ionic hydrogels. Macromolecules 33: 4087-4093. .
  29. Finger, T. and S.A. Simon (2000) The Cell Biology of Lingual Epithelia In: Neurobiology of Taste, Vol. 2. Chapter 12. (T. Finger, W. L. Silver and D. Restrepo, eds). Wiley-Liss, pp. 287-314. .
  30. Katz, D.B., M.A.L. Nicolelis and S.A. Simon (2000) Nutrient tasting and signaling mechanisms in the gut IV. There is more to taste than meets the tongue. Am. J. Physiol. 278: G6-G9. .
  31. Liu, L. and S.A. Simon (2000) Capsaicin, acid and heat evoked currents in rat trigeminal ganglion neurons: Evidence for functional VR1 containing receptors. Physiol. and Behav. 69: 363-378. .
  32. Liu, L., J. Welch, R.P. Erickson, P.H. Reinhart and S.A. Simon (2000) Different responses to repeated applications of zingerone in behavioral studies, recordings from intact and cultured TG neurons, and from VR1 receptors. Physiol. and Behav. 69: 177-186. .
  33. Oortgiesen, M., B. Veronesi, G. Eichenbaum, P. Keiser and S.A. Simon (2000) Residual oil fly ash and negatively charged synthetic polymers activate bronchial epithelial cells and nociceptive sensory neurons. Am. J. Physiol. 278: 683-L695. .
  34. Veronisi, B., M. Oortgiesen, J. Roy, J.D. Carter, S.A. Simon and S.H. Gavett (2000) Vanilliod (capsaicin) receptors influence mouse strain inflammatory sensitivity in response to particulate matter.  Toxicol. and App. Pharmacol. 169:  66-76. .
  35. Welch, J.M., S.A. Simon and P.H. Reinhart (2000) The activation mechanism of VR1 by capsaicin invloves currents in capsaicin-sensitive trigeminal ganglion neurons. Proc. Nat. Acad. Sci. 97: 13889-13894. .
  36. Eichenbaum, G.M., P.F. Kiser, A. Dobrynin, S.A. Simon and D. Needham (1999) Investigation of the swelling response and loading of ionic microgels with drugs and proteins: the dependence on cross-link density. Macromolecules 32(15): 4867-4878. .
  37. Eichenbaum, G.M., P.F. Kiser, S.A. Simon and D. Needham (1999) Investigation of the swelling response and drug loading of ionic microgels: the dependence of functional group composition. Macromolecules 32(26): 8996-9006. .
  38. Katz, D.B., S.A. Simon and M.A.L. Nicolelis (1999) Simultaneous reorganization in thalamocortical ensembles evolves over several hours following perioral capsaicin injections. J. Neurophysiol. 82: 963-977. .
  39. McIntosh, T.J., K.G. Kulkarni and S.A. Simon (1999) Lipids that promote or inhibit membrane fusion effect bilayer structure and undulations. Biophys. J. 76: 2090-2098. .
  40. McIntosh, T.J., N. Porter, M. Pollastri and S. A. Simon (1999) Tannic acid and polyphenolic analogs increase adhesion between lipid bilayers by forming interbilayer bridges. In: Plant Polyphenols 2. Chemistry and Biology (Eds. G.G. Gross, R.W. Heminway and T. Yoshida) Plenum Press, New York. .
  41. Voglino, L., S.A. Simon and T.J. McIntosh (1999) Orientation of LamB signal peptides in bilayers: Influence of lipid probes on peptide binding and the interpretation of fluorescence quenching data. Biochemistry 38: 7509-7516. .
  42. Eichenbaum, G., P. Kiser, S.A. Simon and D. Needham (1998) Equilibrium and kinetic volume response of individual synthetic hydrogel microspheres to changes in pH and ionic strength. Macromolecules 31: 5084-5093. .
  43. Liu, L. and S. A. Simon (1998) Responses of cultured rat trigeminal ganglion cells to bitter tastants Chem. Senses 23: 125-130. .
  44. Liu, L. and S. A. Simon (1998) The influence of removing extracellular Ca2+ in the tachyphylaxis responses to capsaicin, zingerone and olvanil in rat trigeminal ganglion neurons. Brain Res. 809:246-252.   Liu L., G.Q. Chang, Y.Q. Jiao and S.A. Simon (1998) Neuronal nicotinic acetylcholine receptors in rat trigeminal ganglia. Brain Res. 809: 238-245. .
  45. Liu, L., A. Szallasi and S. A. Simon (1998) Activation of rat trigeminal ganglion neurons by a non-pungent, resiniferatoxin analogue: phorbol 12-phenylacetate 13 acetate 20-homovanillate Neuroscience 84: 569-581. .
  46. Needham, D., D. Zhelev, T.J. McIntosh and S.A. Simon (1998) Adsorption, molecular, exchange and defect formation in membranes. Current Opinion in Colloid and Interface Science. 3: 511-517. .
  47. Voglino, L., T. J. McIntosh and S.A. Simon (1998)  Modulation of the binding of signal sequences to lipid bilayer membranes by the insertion of dipoles in the interfacial region.  Biochemistry 35: 12241-12252. .
  48. Dahl, M., R. E. Erickson  and  S.A. Simon (1997)  Neural responses for bitter  compounds in rats. Brain Research. 756: 22-34. .
  49. Liu, L. and S. A .Simon (1997) Capsazepine: a vanilloid receptor antagonist,   inhibits nicotinic acetylcholine receptors in rat trigeminal ganglia. Neurosci. Lett. 228:29-32. .
  50. Liu, L.,  Y.I. Yeh, I.-J. Chen and S.A. Simon (1997) The responses of rat trigeminal ganglion neurons to capsaicin and two non-pungent vanilloid receptor agonists: olvanil and glyceryl nonivamide.  J. Neurosci. 17: 4101-4111. .
  51. McIntosh, T. J. and  S.A. Simon (1997) Experimental tests for undulations in lipid bilayers. Progress in Colloid and Polymer Science  103: 95-106. .
  52. Menco, B. Ph. M.,  M. P. Yankova and S.A Simon (1997) Freeze-substitution and post-embedding immunocytochemistry on taste buds and lingual nerves of the rat: G-Proteins, calcitonin-gene related peptide (CGRP) and choline acetyl transferase (ChAT)  Microscopy and Microanalysis 3: 53-69. .
  53. Huh, N. W., N. A. Porter, T. J. McIntosh and  S. A. Simon  (1996)  The interactions of polyphenols with bilayers:  Conditions for increasing bilayer adhesion.  Biophys. J. 71: 3261-3277. .
  54. Liu  L. and S. A. Simon  (1996)  Similarities and differences in the currents activated by capsaicin, piperine and zingerone in rat trigeminal ganglion neurons.  J. Neurophysiol. 76: 1858-1869. .
  55. Liu  L., Y. Wang and S. A. Simon (1996)  Capsaicin induces multiple currents in rat dorsal root ganglion cells.  Pain 64: 191-195. .
  56. Liu, L. and S. A. Simon (1996). Capsaicin-induced currents with distinct desensitization and Ca++ -dependence in rat trigeminal ganglion cells. J. Neurophysiol. 75: 1503-1514. .
  57. McIntosh T. J. and S. A. Simon (1996)  Short-range pressures between lipid bilayer membranes.  Colloids and Interfaces. 116: 251-268 .
  58. McIntosh, T. J., S. A. Simon, P. Vierling, C. Santaella and V. Ravily (1996) Structure and interactive properties fluorinated phospholipid bilayers.  Biophys. J. 71: 1853-1868. .
  59. Simon, S. A. and T. J. McIntosh (1996)  Role of water in short-range repulsive and attractive interactions between macromolecules and bilayers.  In:  Cold Spring Harbor Symposium on Quantitative Biology.  Protein Kinesis:  The dynamics of protein trafficking and stability.  Volume 60, pp. 601-608. .
  60. Chang, G.-Q.,  S.R. Vinga and S.A. Simon (1995)  Localization of substance P NK-1 receptors in rat tongue.  Regulatory Peptides 63:85-89. .
  61. Disalvo, E.A. and S.A. Simon (1995)  Permeability and Stability of Lipid Bilayers. Eds. E.A. Disalvo and S.A. Simon, CRC Press, Boca Raton, Fl. .
  62. Kenworthy, A.K., S.A. Simon and T.J. McIntosh  (1995)  Structure and phase behavior of lipid suspensions containing phospholipids with covalently attached polyethylene glycol.  Biophysical J.  68: 1903-1920. .
  63. Liu, L. and S.A. Simon (1995)  Capcaisin and nicotine both activate a subset of rat trigeminal ganglion neurons.  Am. J. Physiol. 270:39:C1807-C1814. .
  64. Liu, L. and S.A. Simon  (1995)  Capsaicin-induced currents with distinct desensitization and Ca++ dependence in rat trigeminal ganglion cells.  J. Neurophysiol. 75: 1503-1514. .
  65. Margolis L., B. Babakov, C .Collin and  S.A. Simon (1995)  Dye-coupling in three dimensional cultures of rat lingual frenulum.  In Vitro Cell Dev. Biol. 31: 456-461. .
  66. McIntosh, T.J. and S.A. Simon  (1995)  Adhesion between phosphatidylethonalamine bilayers.  Langmuir 12:1622-1630. .
  67. McIntosh, T.J., D. Avanti, R. E. Burton, D.V. Zhelev, D. Needham and  S.A. Simon (1995)  InteractD.ions between phosphatidylcholine bilayers containing lysophosphatidylcholine and DAPC:  A test for molecular protrusions.  Biochem. 34: 8520-8532. .
  68. Simon, S.A. (1995) Dazzle 'Em with Style: The art of oral presentation. Book Review, Genet. Res. 65: 250. .
  69. Simon, S.A. and  L. Liu (1995)  The activation of rat trigeminal ganglion neurons by anesthetics and irritants.  Prog. in Anesth. Mech. 3: 521-526. .
  70. Simon, S.A., S .Advani and T.J. McIntosh (1995)  Temperature dependence of the repulsive pressure between phosphatidylcholine bilayers. Biophys. J. 69: 1473-1483. .
  71. Wang, Y., R.P. Erickson  and S.A. Simon (1995)  Modulation of rat chorda tympani nerve activity by lingual nerve stimulation.  J. Neurophysiol. 73: 1468-1483. .
  72. Disalvo, E. A. and S. A. Simon  (1994)  Permeability and Stability of Lipid Bilayers, E. A. Disalvo and S. A. Simon (Eds) CRC Press, Boca Raton, FL. .
  73. Liu, L. and S. A. Simon (1994) A rapid capsaicin-current in trigeminal ganglion cells. Proc. Natl. Acad. Sci. (USA) 91: 738-741. .
  74. Liu, L., Y. Wang and S.A. Simon (1994)  Capsaicin induces multiple currents in rat dorsal root ganglion cells.  Pain. (accepted with revisions). .
  75. McIntosh, T. J. and S. A. Simon (1994)   Long-and short-range interactions between phospholipid/ganglioside GM1 bilayers.  Biochemistry 33: 10477-10486. .
  76. McIntosh, T. J. and S. A. Simon  (1994)  Hydration and steric pressures between phospholipid bilayers in Annual Review of Biophysics and Biomolecular Structure.  23: 27-51. .
  77. Simon, S. A., E. A . Disalvo,  K. Gawrisch,  E. Toone, S. Schiffman,  D. Needham and T. J.McIntosh (1994)  Increased adhesion between neutral lipid bilayers:  Tannic acid forms bridges between opposing phosphatidylcholine bilayers.  Biophysical J.  66: 1943-1958. .
  78. Wang, Y.,  R. P. Erickson and S. A. Simon (1994)  Modulation of rat chorda tympani nerve activity by lingual nerve stimulation by lingual nerve stimulation. J. Neurophysiology (accepted for publication). .
  79. Liu, L., W. Pugh, H. Ma and  S.A. Simon (1993)  Nicotinic acetylcholine receptors in adult rat trigeminal ganglion neurons.  Brain Research 617:37-42. .
  80. McIntosh, T.J. and S.A.Simon  (1993)  Contributions of hydration and steric (entropic) pressures between phospholipid bilayers.  Biochemistry 32:8374-8384. .
  81. Simon, S.A. (1993) An enthalpic model of anesthesia. Biophysical J. 64: 1272. .
  82. Simon, S.A., V.F. Holland, D.J. Benos and G.A. Zampighi (1993)  Transport pathways in lingual epithelia.  Microscopy Research and Techniques 26: 196-208. .
  83. Simon, S.A.,  E.F. Elliott, V.F. Holland and R.P. Erickson  (1993)  Ion transport across lingula epithelia is modulated by chorda tympani nerve.  Brain Research 615:218-228. .
  84. Wang, Y., R.P. Erickson and  S.A.Simon (1993)  Selectivity of lingual nerve fibers to chemical stimuli.  J. Gen. Physiol. 101:843-866. .
Biomedical Engineering Department
Pratt School of Engineering | Duke University
Room 136 Hudson Hall • Box 90281 • Durham, NC 27708-0281
Phone: (919) 660-5131 • Fax: (919) 684-4488