Papers Published

1. McIntyre, C.C. and Grill, W.M. and Sherman, D.L. and Thakor, N.V., Model-based analysis of deep brain stimulation of the thalamus, Conference Proceedings. Second Joint EMBS-BMES Conference 2002. 24th Annual International Conference of the Engineering in Medicine and Biology Society. Annual Fall Meeting of the Biomedical Engineering Society (Cat. No.02CH37392), vol. vol.3 (2002), pp. 2047 - 8 [IEMBS.2002.1053160] .
   (last updated on 2007/04/13)

   Abstract:
   High-frequency (~150 Hz) deep brain stimulation (DBS) represents a rapidly emerging therapy in the treatment of medically refractory movement disorders. However, fundamental questions remain about the effects of DBS at both the single cell and network levels. We determined the effects of high frequency stimulation of the thalamus using the combination of a finite element model of the DBS electrode, a multi-compartment cable model of a thalamocortical relay neuron, and a large-scale neural network model of the thalamocortical system. The results show that DBS has an excitatory effect on neural elements near the electrode, and this thalamic excitation results in increased cortical activity. This study supports the hypothesis of excitation-induced changes in network activity as a therapeutic mechanism of DBS

   Keywords:
   bioelectric phenomena;biomechanics;brain models;cellular biophysics;finite element analysis;neural nets;neurophysiology;