Journal Articles

1. Shen, K; Logan, AWJ; Colell, JFP; Bae, J; Ortiz, GX; Theis, T; Warren, WS; Malcolmson, SJ; Wang, Q, Diazirines as Potential Molecular Imaging Tags: Probing the Requirements for Efficient and Long-Lived SABRE-Induced Hyperpolarization., Angewandte Chemie (International ed. in English), vol. 56 no. 40 (September, 2017), pp. 12112-12116 [doi] .
   (last updated on 2024/04/25)

   Abstract:
   Diazirines are an attractive class of potential molecular tags for magnetic resonance imaging owing to their biocompatibility and ease of incorporation into a large variety of molecules. As recently reported, ¹⁵ N₂ -diazirine can be hyperpolarized by the SABRE-SHEATH method, sustaining both singlet and magnetization states, thus offering a path to long-lived polarization storage. Herein, we show the generality of this approach by illustrating that the diazirine tag alone is sufficient for achieving excellent signal enhancements with long-lasting polarization. Our investigations reveal the critical role of Lewis basic additives, including water, on achieving SABRE-promoted hyperpolarization. The application of this strategy to a ¹⁵ N₂ -diazirine-containing choline derivative demonstrates the potential of ¹⁵ N₂ -diazirines as molecular imaging tags for biomedical applications.