Prof. Ramanujam's group is innovating on optical strategies to peer into the biological landscape of thick tissues. Technologies being developed in her lab leverage principles of optical spectroscopy, optical sectioning microscopy, and molecular imaging. Her research group is developing and applying these optically based tools for three problems in cancer: cancer screening in resource-limited settings, intra-operative margin assessment to detect residual disease during cancer surgery and visualizing tumor hypoxia and metabolism in the context of cancer therapy and drug discovery. Prof. Ramanujam is leading a multi-disciplinary effort to translate these technologies to clinical applications in the breast, cervix and head and neck cancers. In addition to her academic efforts, Prof. Ramanujam has spun out a company, Zenalux to commercialize several of the technologies developed in her lab.

Prof. Ramanujam has received several awards for her work in cancer research and technology development. She received the TR100 Young Innovator Award from MIT in 2003, a $2.5M DOD Era of Hope Scholar award in 2004, the Global Indus Technovator award from MIT in 2005 and a $3M Era of Hope Research Scholar award in 2009. Dr. Ramanujam was recently elected as fellow of OSA and she has been invited to be a member of the DOD’s breast cancer research program (BCRP) integration panel (IP) that sets the vision of the BCRP program and plans the dissemination of over $100 M of funds for breast cancer research annually. She is co-editor for the latest edition of the Handbook of Biomedical Optics (publisher Taylor and Francis). In 2011, she received the Stansell Family Distinguished Research Award from the Pratt School of Engineering at Duke University.

Dr. Ramanujam earned her Ph.D. in Biomedical Engineering from the University of Texas, Austin in 1995 and then trained as an NIH postdoctoral fellow at the University of Pennsylvania from 1996-2000. Prior to her tenure at Duke, she was an assistant professor in the Dept. Biomedical Engineering at the University of Wisconsin, Madison from 2000-2005.

Contact Info:

Office Location:	2575 FCIEMAS
Office Phone:	(919) 660-5307
Email Address:
Web Page:	http://nimmi.bme.duke.edu/

Education:

PhD, University of Texas, Austin, 1995

Curriculum Vitae

Specialties:

Medical Imaging
Photonics
Cancer diagnostics and therapy
Medical Instrumentation
Medical Diagnostics

Awards, Honors, and Distinctions

Advisory Board Member, Dept. Biomedical Engineering, University of Texas, Austin, 2011 - 2014
Stansell Distinguished Research Award, Pratt School of Engineering, Duke University, 2011
Fellow, Optical Society of America, 2009
Standing Member, DOD Breast Cancer Research Program Integration Panel, 2009
Invited Speaker, Gordon Conference on Lasers in Medicine and Biology, December, 2008
Plenary Speaker, DOE Era of Hope Breast Cancer Conference, December, 2008
Global Indus Technovators Awards, Indian Business Club at MIT, 2005
Technology achievement award, MIT Alumni Association of Wisconsin, 2005
Vilas Associate award, University of Wisconsin, Madison, 2005
Era of Hope Scholar Award, DOD Breast Cancer Research Program, 2004
Invited speaker, Gordon Conference on Lasers in Medicine and Biology, 2004
TR100 Young Innovator Award, Selected as one of the top 100 young innovators in technology in the world by MIT's Technology Review Magazine, 2003
Whitaker travel award to participate in the ASEE Conference, 2002
Fellow, American Society of Laser Medicine and Surgery, December, 2001
Whitaker Foundation investigator, 2001
Invited participant in NSF’s “Engineering Education Scholars Workshop”, 1996
National Research Service Award, National Institutes of Health, 1996
One of three finalists in the American Association for Medical Instrumentation Young Investigator Competition, 1996
Scholarship, Association for Women in Science Educational Foundation, November, 1995
Award for Best Scientific Paper, American Association of Cancer Research, 1995
Scholarship, American Society for Laser Medicine & Surgery, 1995
Scholarship, International Society for Optical Engineering, November, 1994
Professional Development Award, University of Texas, Austin, 1994 - 1995
Award for Best Scientific Paper, American Society for Laser Medicine & Surgery, 1994-95

Selected Patents

• Optical Assay System for Intra Operative Assessment of Tumor Margins.      
• Methods, Systems and Computer Program Products for Optimization of Probes for Spectroscopic Measurement in Turbid Media, 7835786.      
• Monte carlo based model of fluorescence in turbid media and methods and systems for using same to determine intrinsic fluorescence of turbid media, 7818154.      
• Optical Assay System for Intra Operative Assessment of Tumor Margins, 7751039.      
• Method for extraction of optical properties from diffuse reflectance spectra, 7,570,988 B2.      
• Depth-resolved reflectance instrument and method for its use, 7440659.      
• Method for probabilistically classifying tissue in vitro and in vivo using fluorescence spectroscopy, 7236815.      
• Depth-resolved fluorescence instrument with angled excitation, 7202947.      
• Depth-resolved fluorescence instrument, 6825928.      
• Diagnostic method and apparatus for cervical squamous intraepithelial lesions in vitro and in vivo using fluorescence spectroscopy, 7202947.      
• Spectroscopic detection of cervical pre-cancer using radial basis function networks, 6135965.      
• Spectroscopic method and apparatus for optically detecting abnormal mammalian epithelial tissue, 6095982.      
• Near-infrared raman spectroscopy for in vitro and in vivo detection of cervical precancers, 5991653.      
• Optical method and apparatus for the diagnosis of cervical precancers using raman and fluorescence spectroscopies, 5697373.      
• Diagnosis of dysplasia using laser induced fluorescence, 5623932.      
• Diagnosis of dysplasia using laser induced fluorescence, 5421339.      
• Depth-resolved fluorescence instrument.      
• Method and apparatus for probabilistically classifying tissue in vitro and in vivo using fluorescence spectroscopy.      
• Depth-resolved fluorescence instrument with angled excitation.      
• Side-firing probe for performing optical spectroscopy during core needle.      
• Method for extraction of optical properties from diffuse reflectance spectra.      
• Methods, systems, and computer program products for optimization of probes for spectroscopic measurement in turbid media.      
• Depth-resolved reflectance instrument and method for its use.      
• Monte Carlo based model of fluorescence in turbid media and methods and systems for using same to determine intrinsic fluorescence of turbid media.      
• Optical assay system for intraoperative assessment of tumor margins.      
• Scaling method for fast monte carlo simulation of diffuse reflectance spectra from multi-layered turbid media and methods and systems for using same to determine optical properties of multi-layered turbid medium from measured diffuse reflectance.      
• Systems and methods for spectral analysis of a tissue mass using an instrument, an optical probe, and a monte carlo or a diffusion algorithm.      
• Optical assay system with a multi-probe imaging array.      
• Integrated miniaturized fiber optic probe.      
• Optical assay system for intraoperative assessment of tumor margins.      

Representative Publications   (More Publications)

1. Chang VTC, Cartwright PS, Bean SM, Palmer GM, Bentley RC, Ramanujam N., Quantitative physiology of the precancerous cervix in vivo via optical spectroscopy, Neoplasia, vol. 11 no. 4 (2009), pp. 325-332 .
2. J. Q. Brown and L. G. Wilke and J. Geradts and S. A. Kennedy and G. M. Palmer and N. Ramanujam, Quantitative Optical Spectroscopy: A Robust Tool for Direct Measurement of Breast Cancer Vascular Oxygenation and Total Hemoglobin Content In vivo, Cancer Research, vol. 69 no. 7 (April, 2009), pp. 2919 -- 2926  [abs].
3. K. Vishwanath and D. Klein and K. Chang and T. Schroeder and M. W. Dewhirst and N. Ramanujam, Quantitative optical spectroscopy can identify long-term local tumor control in irradiated murine head and neck xenografts, Journal Of Biomedical Optics, vol. 14 no. 5 (September, 2009)  [abs].
4. L. G. Wilke and J. Q. Brown and T. M. Bydlon and S. A. Kennedy and L. M. Richards and M. K. Junker and J. Gallagher and W. T. Barry and J. Geradts and N. Ramanujam, Rapid noninvasive optical imaging of tissue composition in breast tumor margins, American Journal Of Surgery, vol. 198 no. 4 (October, 2009), pp. 566 -- 574  [abs].
5. J.H. Ostrander, C.M. McMahon, S. Lem, S.R. Millon, V.L. Seewaldt, N. Ramanujam, The Optical Redox Ratio Differentiates Breast Cancer Cell Lines Based on Receptor Status, Cancer Research, vol. 70 no. 11 (2010), pp. 4759-4766 .
6. Millon SR, Ostrander JH, Brown JQ, Rajeha AM, Seewaldt VL, Ramanujam N, Uptake of 2-NBDG as a method to monitor therapy response in breast cancer cell lines, Breast Cancer Research and Treatment, vol. 126 no. 1 (2011), pp. 55-62 .

Selected Grant Support

• Smart Optical Sensor for Detection of Cervical Cancer In the Developing World, National Institutes of Health, 1R21CA162747-01.      
• A Novel Optical Spectral Imaging System for Rapid Imaging of Breast Tumor Margins, National Institutes of Health, 1R01-EB011574-01.      
• Harnessing the power of light to see and treat breast cancer, United States Army Medical Research and Materiel Command, W81XWH-09-1-0410.      
• Biosensor Biocompatibility, National Institutes of Health, 2R01-DK-54932.      
• Fast Spectral Imaging Device for Tumor Margin Mapping, National Institutes of Health, 2R42CA128160-02.      
• Can Optical Spectroscopy Predict Early Treatment Response in Solid Tumors, National Cancer Institute, 5K99CA140783-02.      
• A smart fiber optic sensor for in vivo tissue optical spectroscopy, National Institutes of Health, 1R03EB012210-01.      
• A Fluorescence Histology System for In Vivo Breast Tumor Margin Assessment, National Institutes of Health, 1R21CA159936-01.      
• Use of Diffuse Reflectance Spectroscopy to Assess Tumor Biomarkers that predict outcomes in Head and Neck Cancer Therapy, Duke University.      
• Is high glucose uptake at target for early detection and prevention of triple-negative breast cancer?, Susan G. Komen Breast Cancer Foundation.