Michael R. Zalutsky, Professor, Department of Radiology, Radiation Oncology and Biomedical Engineering and Jonathan Spicehandler M.D. Professor of Neuro-Oncology Research  

Michael R. Zalutsky
Contact Info:
Office Location:  311 Research Drive
Email Address:   send me a message
Web Page: http://cmb.duke.edu/faculty/zalutsky.html


Ph.D., Washington University, 1974
M.A., Washington University, 1972

Medical Imaging
Polymer and Protein Engineering
Representative Publications   (More Publications)

  1. Larsen, RH, Akabani G, Welsh P, Zalutsky MR. The cytotoxicity and microdosimetry of 211AT-labeled chimeric monoclonal antibodies on human glioma and melanoma cells in vitro. Radiation Res. 1998; 149:155-162 .
  2. Larsen RH, Vaidyanathan G, Zalutsky MR. The cytotoxicity of a-particle emitting 5-[211At]astato2'-deoxyuridine in human cancer cells. Int J Radiation Biol. 1997; 72:79-90 .
  3. Reist CJ, Archer GE, Wikstrand CJ, Bigner DD, Zalutsky MR. Improved targeting of an anti-EGFRvIII monoclonal antibody in tumor xenografts after labeling using N-succinimdyl 5-iodo-3-pyridinecarboxylate. Cancer Res., 1997; 57:1510-1515 .
  4. 4. Vaidyanathan, G., Larsen, R.H., and Zalutsky, M.R.:5-[211At]astato-2\'-deoxyuridine, an à-particle emitting endoradiotherapeutic agent undergoing DNA incorporation. Cancer Res. 1996; 56:1204-1209. .
  5. 5. Reist, C.J., Garg, P.K., Alston, K.L., Bigner, D.D., and Zalutsky, M.R.: Radioiodination of internalizing monoclonal antibodies using N-succinimidyl 5-iodo-3-pyridine-carboxylate: in vitro studies. Cancer Res., 1996;56:4970-4977. .
  6. Olafsen T, Brugland S, Zalutsky MR, Sandlie I. Cloning and sequencing of V genes from anti-osteosarcoma monoclonal antibodies TP-1 and TP-3: Location of lysine residues and implications for radiolabeling. Nucl Med Biol 1995; 22:765-772 .
  7. 2. Zalutsky, M.R., McLendon, R., Garg, P.K., Archer, G.E., Schuster, J.M., and Bigner, D.D.: Radioimmunotherapy of neoplastic meningitis in rats using an à-particle-emitting immunoconjugate. Cancer Res. 1994;54:4719-4725. .
  8. 3. Page, R.L., Garg, P.K., Garg, S., Archer, G.E., Bruland, .S., and Zalutsky, M.R.: Positron emission tomographic imaging of osteosarcoma in dogs using an 18F-labeled monoclonal antibody Fab fragment. J. Nucl. Med. 1994; 35:1506-1513. .
  9. 1. Zalutsky, M.R., Garg, P.K., Friedman, H.S., and Bigner, D.D.: Labeling monoclonal antibodies and F(ab')2 fragments with the alpha particle emitting nuclide astatine-211: preservation of immunoreactivity and in vivo localizing capacity. Proc. Natl. Acad. Sci. USA 1989;86:7149-7153. .