| Kam W. Leong, James B. Duke Professor of Biomedical Engineering and Center for Biologically Inspired Materials and Material Systems
Please note: Kam has left the "Center for Biologically Inspired Materials and Material Systems" group at Duke University; some info here might not be up to date. Professor Leong's research interest focuses on biomaterials design, particularly on synthesis of nanoparticles for DNA-based therapeutics, and nanostructured biomaterials for regenerative medicine
Biomaterials Design:
- design of self-assembled fibers for tissue engineering
- microfluidics-mediated synthesis of multifunctional nanoparticles for drug and gene delivery
- synthesis of novel quantum dots for biomedical applications
Controlled Drug and Gene Delivery:
- oral gene delivery for hemophilia A and B
- non-viral gene delivery to the GI tract
- oral delivery of antigen genes for vaccination
Tissue Engineering:
- study of response of stem cells to nanotopographical cues
- expansion of hematopoietic stem cells
- nerve guidance channels with drug and gene delivery functions
- microencapsulation of stem cells and genetically-engineered cells
- development of bioartificial nucleus pulposus device
- study of interaction of stem cells with synthetic nanostructured biomaterials
- Contact Info:
- Education:
PhD | University of Pennsylvania | 1987 |
Postdoc | Massachusetts Institute of Technology (MIT) | 1985 |
BS | University of California | 1977 |
- Specialties:
-
Biological Materials
Drug Delivery Tissue Repair, Tissue Engineering Biophotonics Nanoscience
- Curriculum Vitae
- Representative Publications
(More Publications)
- Ho, Y. P. and Leong, K. W., Quantum dot-based theranostics,
Nanoscale, vol. 2 no. 1
(2010),
pp. 60-68 [PDF] [abs]
- Yim, E. K. F. and Darling, E. M. and Kulangara, K. and Guilak, F. and Leong, K. W., Nanotopography-induced changes in focal adhesions, cytoskeletal organization, and mechanical properties of human mesenchymal stem cells,
Biomaterials, vol. 31 no. 6
(2010),
pp. 1299-1306 [PDF] [abs]
- Chen, S. and Jones, J. A. and Xu, Y. and Low, H. Y. and Anderson, J. M. and Leong, K. W., Characterization of topographical effects on macrophage behavior in a foreign body response model,
Biomaterials, vol. 31 no. 13
(2010),
pp. 3479-91 [PDF] [abs]
- Chen, H. H. and Ho, Y. P. and Jiang, X. and Mao, H. Q. and Wang, T. H. and Leong, K. W., Simultaneous non-invasive analysis of DNA condensation and stability by two-step QD-FRET,
Nano Today, vol. 4 no. 2
(2009),
pp. 125-134 [PDF] [abs]
- Oney, S. and Lam, R. T. S. and Bompiani, K. M. and Blake, C. M. and Quick, G. and Heidel, J. D. and Liu, J. Y. C. and Mack, B. C. and Davis, M. E. and Leong, K. W. and Sullenger, B. A., Development of universal antidotes to control aptamer activity,
Nature Medicine, vol. 15 no. 10
(2009),
pp. 1224-1228 [PDF] [abs]
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