Center for Biologically Inspired Materials and Material Systems Center for Biologically Inspired Materials and Material Systems
Pratt School of Engineering
Duke University

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Publications [#263324] of Stefan Zauscher

Papers Published

  1. Gu, R; Lamas, J; Rastogi, SK; Li, X; Brittain, W; Zauscher, S, Photocontrolled micellar aggregation of amphiphilic DNA-azobenzene conjugates., Colloids and Surfaces B: Biointerfaces, vol. 135 (November, 2015), pp. 126-132, ISSN 0927-7765 [doi]
    (last updated on 2018/05/21)

    We demonstrate the reversible micellar aggregation of a DNA-azobenzene conjugate in aqueous conditions, in which the photoisomerization of the initially apolar trans-azobenzene moiety to the polar cis isomer causes disassembly of the aggregates. The molecular basis for this phenomena is a change in the hydrophobic/hydrophilic balance of the conjugate as the more polar cis azobenzene isomer is formed upon exposure to 365 nm irradiation. The conjugates were prepared by copper-free Click chemistry between an azide-modified, 53-base ssDNA and a cyclooctyne derivative of azobenzene. The photocontrolled aggregation of the conjugate was studied by dynamic light scattering and atomic force microscopy. The reversible micellar aggregation for a DNA-azobenzene conjugate has not been previously reported and holds promise for photocontrolled drug delivery applications.

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