Publications [#168939] of Mark W. Dewhirst

Papers Published

1. JA Tashjian, MW Dewhirst, D Needham, BL Viglianti, Rationale for and measurement of liposomal drug delivery with hyperthermia using non-invasive imaging techniques., International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, England, vol. 24 no. 1 (February, 2008), pp. 79-90, ISSN 0265-6736
   (last updated on 2009/12/31)

   Abstract:
   The purpose of this review is to present an overview of the state-of-the-art imaging modalities used to track drug delivery from liposomal formulations into tumors during or after hyperthermia treatment. Liposomes are a drug delivery system comprised of a phospholipid bilayer surrounding an aqueous core and have been shown to accumulate following hyperthermia therapy. Use of contrast-containing liposomes in conjunction with hyperthermia therapy holds great promise to be able to directly measure drug dose concentrations as well as to non-invasively describe patterns of drug distribution with MR and PET/SPECT imaging modalities. We will review the rationale for using this approach and the potential advantages of having such information available during and after treatment.

   Keywords:
   Animals • Antineoplastic Agents • Humans • Hyperthermia, Induced • Liposomes • Magnetic Resonance Imaging • Nanoparticles • Neoplasms • Rats • Tissue Distribution • Tomography, Emission-Computed, Single-Photon • administration & dosage • drug therapy* • methods* • pharmacokinetics • pharmacokinetics*