Publications [#63204] of Mark W. Dewhirst

Papers Published

1. Thrall, D.E. and Prescott, D.M. and Samulski, T.V. and Rosner, G.L. and Denman, D.L. and Legorreta, R.L. and Dodge, R.K. and Page, R.L. and Cline, J.M. and Jihjong Lee and Case, B.C. and Evans, S.M. and Oleson, J.R. and Dewhirst, M.W., Radiation plus local hyperthermia versus radiation plus the combination of local and whole-body hyperthermia in canine sarcomas, Int. J. Radiat. Oncol. Biol. Phys. (USA), vol. 34 no. 5 (1996), pp. 1087 - 96 [0360-3016(95)02260-0]
   (last updated on 2007/04/14)

   Abstract:
   The purpose of this study was to assess the effect of increasing intratumoral temperatures by the combination of local hyperthermia (LH) and whole body hyperthermia (WBH) on the radiation response of canine sarcomas. Dogs with spontaneous soft tissue sarcomas and no evidence of metastasis were randomized to be treated with radiation combined with either LH alone or LH+WBH. Dogs were accessioned for treatment at 2 institutions. The radiation dose was 56.25 Gy, given in 25 2.25 Gy daily fractions. Two hyperthermia treatments were given; 1 during the first and 1 during the last week of treatment. Dogs were evaluated after treatment for local recurrence, metastasis, and complications. Sixty-four dogs were treated between 1989 and 1993. The use of LH+WBH resulted in statistically significant increases in the low and middle regions of the temperature distributions. The largest increase was in the low temperatures with median CEM 43 T90 values of 4 vs. 49 min for LH vs. LH+WBH, respectively (p<0.001). There was no difference in duration of local tumor control between hyperthermia groups (p=0.59). The time to metastasis was shorter for dogs receiving LH+WBH (p=0.02); the hazard ratio for metastatic disease for dogs in the LH+WBH group was 2.5 (95% confidence interval, 1.2-5.4) with respect to dogs in the LH group. Complications were greater in larger tumors and in tumors treated with LH+WBH. It is concluded that the combination of LH+WBH with radiation therapy, as described herein, was not associated with an increase in local tumor control in comparison to use of LH with radiation therapy. The combination of LH+WBH also appeared to alter the biology of the metastatic process and was associated with more complications than LH. The authors identified no rationale for further study of LH+WBH in combination with radiation for treatment of solid tumors

   Keywords:
   hyperthermia;radiation therapy;temperature distribution;