Publications [#63205] of Mark W. Dewhirst

Papers Published

1. McChesney Gillette, S. and Dewhirst, M.W. and Gillette, E.L. and Thrall, D.E. and Page, R.L. and Powers, B.E. and Withrow, S.J. and Rosner, G. and Wong, C. and Sim, D.A., Response of canine soft tissue sarcomas to radiation or radiation plus hyperthermia: a randomized phase II study, Int. J. Hyperth. (UK), vol. 8 no. 3 (1992), pp. 309 - 20
   (last updated on 2007/04/14)

   Abstract:
   Sixty-four dogs with spontaneous soft tissue sarcomas without evidence of metastases were stratified by tumor volume and randomized to receive graded doses of radiotherapy (XRT) alone or radiotherapy plus hyperthermia (HT). An improvement in duration of local control was achieved with the addition of hyperthermia as compared with XRT alone (Wilcoxon, p=0.040; log range, p=0.064). Overall frequency of late complications was not different for the two treatment arms when comparing across equivalent XRT dose groups. Frequency of distant metastases after therapy completion was not significantly different for the two treatment arms at one year (7.4% for XRT versus 20% for HT plus XRT) or two years (11.5% for XRT versus 25% for HT plus XRT) post therapy. These results suggest that a therapeutic gain was achieved for this group of tumour-bearing animals. Uni- and multivariate analyses were performed to examine the potential for various factors to influence treatment outcome

   Keywords:
   biothermics;radiation therapy;