Publications [#63232] of Mark W. Dewhirst

Papers Published

1. Vujaskovic, Z. and Rosen, E.L. and Blackwell, K.L. and Jones, E.L. and Brizel, D.M. and Prosnitz, L.R. and Samulski, T.V. and Dewhirst, M.W., Ultrasound guided pO₂ measurement of breast cancer reoxygenation after neoadjuvant chemotherapy and hyperthermia treatment, Int. J. Hyperth. (UK), vol. 19 no. 5 , pp. 498 - 506 [0265673031000121517]
   (last updated on 2007/04/14)

   Abstract:
   The objective of this study was to determine whether neoadjuvant chemotherapy in combination with hyperthermia (HT) would improve oxygenation in locally advanced breast tumours. The study describes a new optimized ultrasound guided technique of pO₂ measurement using Eppendorf polarographic oxygen probes in 18 stage IIB-III breast cancer patients. Prior to treatment, tumour hypoxia (median pO₂<10mmHg) was present in 11/18 patients (average median pO₂=3.2 mmHg). Seven patients had well oxygenated tumours (median pO₂ of 48.3 mmHg). Eight patients with hypoxic tumours prior to treatment had a significant improvement (p=0.0008) in tumour pO₂after treatment (pO₂ increased to 19.2 mmHg). In three patients, tumours remained hypoxic (average median pO₂=4.5mmHg). The advantages of the ultrasound guided pO₂ probe are in the accuracy of the Eppendorf electrode placement in tumour tissue, the ability to monitor electrode movement through the tumour tissue during the measurement and the ability to avoid electrode placement near or in large blood vessels by using colour Doppler imaging. The results of this preliminary study suggest that the combination of neoadjuvant chemotherapy and hyperthermia improves oxygenation in locally advanced breast tumours that are initially hypoxic

   Keywords:
   biomedical electrodes;biomedical measurement;biomedical optical imaging;biomedical ultrasonics;blood vessels;cancer;hyperthermia;mammography;oxygen;polarography;surgery;tumours;