Publications [#63234] of Mark W. Dewhirst

Papers Published

1. Leopold, K.A. and Dewhirst, M.W. and Samulski, T.V. and Dodge, R.K. and George, S.L. and Blivin, J.L. and Prosnitz, L.R. and Oleson, J.R., Cumulative minutes with T₉₀ greater than temp_index is predictive of response of superficial malignancies to hyperthermia and radiation, Int. J. Radiat. Oncol. Biol. Phys. (UK), vol. 25 no. 5 (1993), pp. 841 - 7
   (last updated on 2007/04/14)

   Abstract:
   Patients were randomized to receive one or two hyperthermia treatments per week with hyperthermia given during each week of irradiation. Hyperthermia was given for 60 min with treatments begun within 1 hr following irradiation. Power was increased to patient tolerance or normal tissue temperature of 43.0°C. Irradiation was generally given 5 times per week with doses prescribed to normal tissue tolerance (generally 24-70 Gy at 1.8-2.5 Gy per fraction). Multipoint thermometry was used with temperatures obtained every 5 min. One hundred eleven individual treatment fields containing 1 or more tumor modules were completely evaluable. The complete and overall response rates were 46% and 80%, respectively. Forty-one percent of all treatment fields (51% of responding lesions) remained controlled at 2 years. Multivariate analysis revealed that the cumulative minutes that the temperature achieved by 90% of the measured tumor sites (T₉₀) was ⩾40.0°C, tumor histology, tumor volume, and radiation dose were significantly associated with complete tumor response. The complete response rate was not significantly affected by the number of hyperthermia treatments given per week. The incidence of clinically significant complications was low

   Keywords:
   biothermics;radiation therapy;