Publications [#63268] of Mark W. Dewhirst

Papers Published

1. Oleson, J.R. and Dewhirst, M.W. and Harrelson, J.M. and Leopold, K.A. and Samulski, T.V. and Tso, C.Y., Tumor temperature distributions predict hyperthermia effect, Int. J. Radiat. Oncol. Biol. Phys. (UK), vol. 16 no. 3 (1989), pp. 559 - 70
   (last updated on 2007/04/14)

   Abstract:
   Proposes a model that is based upon noting that the majority of a tumor volume is contained in the outermost `shell' of a solid tumor, across which shell the radial temperature distribution is assumed to be linear. Any linear distribution can be defined by coordinates of a point and a slope, and the authors choose the temperature at the radiographically defined edge of a tumor and the slope (dT/dr) across the outer shell as these determinants of the linear radial temperature distribution. A discriminant analysis of success or failure of treatment can then be based upon these two descriptors (T_edge, dT/dr). The authors have tested this model using data from patients with soft tissue sarcoma (Stage IIB or greater). The authors' model has an 86% predictive value for lack of complete or nearly complete necrosis in the resected specimen according to whether the time-averaged T_edge and slope during each HT treatment satisfy the equation T_edge+1.2 (slope in °C/cm)⩽40.6°C in all but one treatment at most

   Keywords:
   biothermics;patient treatment;physiological models;temperature distribution;