Publications [#63274] of Mark W. Dewhirst

Papers Published

1. Acker, J.C. and Dewhirst, M.W. and Honore, G.M. and Samulski, T.V. and Tucker, J.A. and Oleson, J.R., Blood perfusion measurements in human tumours: evaluation of laser Doppler methods, Int. J. Hyperth. (UK), vol. 6 no. 2 (1990), pp. 287 - 304
   (last updated on 2007/04/14)

   Abstract:
   Laser Doppler flowmetry is a simple method of determining, directly and continuously, tissue blood flow. However, its applicability to monitoring tumour blood flow interstitially during hyperthermia treatments is still being evaluated. The purposes of this study were to physically characterize the measurement probes, to evaluate potential sources of artifact with the interstitial use of the probes during hyperthermia treatment, and to obtain measurements in human tumours during hyperthermia sessions. The accuracy of the method in quantifying blood flow, velocity and volume during hyperthermia was found to be unaffected by heating the measurement probe to 42-46°C or by exposing it to various intensities of 915 MHz microwave fields (10-40 W), or 1 MHz ultrasound fields. Catheter insertion methods were developed to place the flow probes interstitially in tumours. Tissue damage was confined to a distance of no greater than 0.12 mm away from the catheter tract, and physical evidence of vascular disruption was within a distance of 0.05 mm as measured in a rat tumour model. This degree of damage/disruption is unlikely to affect LDF measurements which represent blood flow averaged over a 1.0-1.5 mm radius from the probe tip

   Keywords:
   biomedical measurement;blood;Doppler effect;laser applications in medicine;patient treatment;