Center for Biomolecular and Tissue Engineering Center for Biomolecular and Tissue Engineering
Pratt School of Engineering
Duke University

 HOME > pratt > CBTE    Search Help Login pdf version printable version 

Publications [#64516] of Bruce M. Klitzman

Papers Published

  1. Skarada, Douglas J. and Erickson, Geoffrey R. and Warnecke, Kindra L. and du Laney, Tracey V. and Greenberg, Charles S. and Ritter, Edmond F. and Klitzman, Bruce, Assessments of thrombogenicity by three in vitro techniques, Journal of Biomedical Materials Research, vol. 29 no. 9 (1995), pp. 1039 - 1045
    (last updated on 2007/04/15)

    Three in vitro techniques designed to measure the thrombogenicity of vascular grafts are assessed. All techniques immerse vascular grafts in rotating blood. In the gravimetric analysis, the weight of adherent thrombi is recorded at 2 min intervals for 20 min. In the torque analysis, a microviscometer continuously recorded the amount of torque developed as the graft rotated for 20 min. In the thrombin analysis, the blood sample is analyzed for fibrinopeptide a production indicating fibrinogen cleavage. Expanded polytetrafluoroethylene graft are treated by removal of air nuclei, binding of heparin, or binding of polyethylene oxide.

    Blood;Gravimetric analysis;Torque;Viscometers;Coagulation;Coatings;Amino acids;Polyethylene oxides;

Duke University * Pratt * CBTE * Reload * Login