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Pratt School of Engineering
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Publications [#64517] of Bruce M. Klitzman

Papers Published

  1. Sharkawy, A. Adam and Klitzman, Bruce and Truskey, George A. and Reichert, W. Monty, Engineering the tissue which encapsulates subcutaneous implants. II. Plasma-tissue exchange properties, Journal of Biomedical Materials Research, vol. 40 no. 4 (1998), pp. 586 - 597 [(SICI)1097-4636(19980615)40:4<586::AID-JBM10>3.3.CO;2-V]
    (last updated on 2007/04/15)

    Plasma-tissue exchange properties of the capsular tissue were studied to determine the effects of implant porosity. The number of vessels and permeability to rhodamine were measured by intravascular injection of fluorophore tracer in to rats that hosted polyvinyl alcohol (PVA) and polytetrafluoroethylene (PTFE) implants. The permeability of the vessels did not vary with implant pore size, but pore size had an effect on the vascular density of tissue-encapsulating implants. Pore sized on the order of cellular dimensions incited neovascularizations. Brightfield microscopy showed the number of vessels around PVA-60 implants was almost double those in normal subcutis.

    Implants (surgical);Porosity;Polyvinyl alcohols;Polytetrafluoroethylenes;Image analysis;Blood vessels;Density (specific gravity);Biocompatibility;

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