Publications [#64524] of Bruce M. Klitzman

Papers Published

1. Secomb, T.W. and Hsu, R. and Dewhirst, M.W. and Klitzman, B. and Gross, J.F., Analysis of oxygen transport to tumor tissue by microvascular networks, Int. J. Radiat. Oncol. Biol. Phys. (UK), vol. 25 no. 3 (1993), pp. 481 - 9
   (last updated on 2007/04/15)

   Abstract:
   Presents theoretical simulations of oxygen delivery to tumor tissues by networks of microvessels, based on in vivo observations of vascular geometry and blood flow in the tumor microcirculation. The aim of these studies is to investigate the impact of vascular geometry on the occurrence of tissue hypoxia. The observations were made in the tissue (thickness 200 μm) contained between two glass plates in a dorsal skin flap preparation in the rat. Mammary adenocarcinomas (R3230 AC) were introduced and allowed to grow, and networks of microvessels in the tumors were mapped, providing data on length, geometric orientation, diameter and blood velocity in each segment. It is concluded that the heterogeneous structure of tumor microcirculation can have a substantial effect on the occurrence of hypoxic micro-regions

   Keywords:
   biotransport;oxygen;