Publications [#64525] of Bruce M. Klitzman

Papers Published

1. Klitzman, Bruce and Ravin, A.G. and Olbrich, K.C. and Levin, L.S. and Usala, A.-L., Long- and short-term effects of biological hydrogels on capsule microvascular density around implants in rats, Journal of Biomedical Materials Research, vol. 58 no. 3 (2001), pp. 313 - 318 [1097-4636(2001)58:3<313::AID-JBM1023>3.0.CO;2-O]
   (last updated on 2007/04/15)

   Abstract:
   Fibrous capsule formation around implants can inhibit solute exchange between implantable devices and the circulation. Parylene-n coated polycarbonate disks surrounded with growth factor reduced Matrigel [registered trademark] (MG) or several gelatin-based matrices were implanted intramuscularly into rats for 21 or 50 days. MG supplemented with vascular endothelial growth factor (VEGF) or basic fibroblast growth factor (bFGF) increased capsule microvascular density at 21 days (p less than or equal 0.05) when compared to bare parylene-coated polycarbonate disks (control). The increased microvascular density around VEGF- and bFGF-treated implants regressed by 50 days and was no longer significantly different from controls. The microvascular density induced by the gelatin-based matrices was not significantly different from controls at 21 days, but was increased at 50 days (p less than or equal 0.05), suggesting a slower, long-term effect. Disks treated with MG and gelatin-based matrices had thinner capsules at 21 days (p less than or equal 0.05). By 50 days, the capsule thicknesses around these implants were no longer statistically thinner than controls. The capsule thickness around implants treated with VEGF, bFGF, and essential gelatin-based matrix was thinner than controls at 50 days (p less than or equal 0.05). These results indicate that it is possible to increase functional microvascular density within fibrous capsules using angiogenic growth factors and gelatin-based matrices. However, this effect may be short-lived, requiring chronic administration of growth factors. © 2001 John Wiley and Sons, Inc.

   Keywords:
   Hydrogels;Implants (surgical);