| Publications [#64530] of Bruce M. Klitzman
Papers Published
- Sharkawy, A. Adam and Klitzman, Bruce and Truskey, George A. and Reichert, W. Monty, Engineering the tissue which encapsulates subcutaneous implants. I. Diffusion properties,
Journal of Biomedical Materials Research, vol. 37 no. 3
(1997),
pp. 401 - 412 [(SICI)1097-4636(19971205)37:3<401::AID-JBM11>3.3.CO;2-X]
(last updated on 2007/04/15)
Abstract: Porous and nonporous polyvinyl alcohol (PVA) and stainless steel cage specimens were implanted in the subcutis of rats to elicit a range of capsular wound-healing tissues and to analyze small analyte transport through the tissue which encapsulates implants. The fibrous capsule forming around a subcutaneously implanted smooth-surface sensor imposes a significant diffusion barrier to small analytes, thus increasing the lag time of the sensor by as much as threefold. A sensor with a porous surface which allows tissue ingrowth may be more responsive to blood analyte fluctuations as a result of its a more vascular and less fibrous encapsulation tissue.
Keywords: Polyvinyl alcohols;Stainless steel;Biosensors;Diffusion in solids;Tissue;Porous materials;Volume fraction;Physiological models;Encapsulation;
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