Center for Biomolecular and Tissue Engineering Center for Biomolecular and Tissue Engineering
Pratt School of Engineering
Duke University

 HOME > pratt > CBTE    Search Help Login pdf version printable version 

Lori A. Setton, Professor of Biomedical Engineering and Mary Milius Yoh and Harold L. Yoh, Jr. Bass Professor of Biomedical Engineering and Associate Professor of Orthopaedic Surgery

Lori A. Setton

Research in Setton's laboratory is focused on the role of mechanical factors in the degeneration and repair of soft tissues of the musculoskeletal system, including the intervertebral disc, articular cartilage and meniscus. Work in the Laboratory is focused on engineering and evaluating materials for tissue regeneration and drug delivery. Studies combining engineering and biology are also used to determine the role of mechanical factors to promote and control healing of cartilaginous tissues. Research in the Laboratory is funded by The National Institutes of Health, The Coulter Foundation and The North Carolina Biotechnology Center.

Contact Info:
Office Location:  355A, Med Sci Res Building
Email Address: send me a message
Web Page:  http://settonlab.pratt.duke.edu/index.htm

Teaching (Spring 2014):

  • BME 530.01, TISSUE BIOMECHANICS Synopsis
    CIEMAS 1466, MW 01:25 PM-02:40 PM
Education:

PhDColumbia University1993
BSPrinceton University1984
Specialties:

Tissue Repair, Engineering
Tissue Repair, Tissue Engineering
Biological Materials
Biological Materials
Curriculum Vitae
Representative Publications   (More Publications)

  1. Gilchrist, Christopher L. and Witvoet-Braam, Sietske W. and Guilak, Farshid and Setton, Lori A., Measurement of intracellular strain on deformable substrates with texture correlation, Journal of Biomechanics, vol. 40 no. 4 (2007), pp. 786 - 794 [013]  [abs]
  2. Li Cao and Youn, I. and Guilak, F. and Setton, L.A., Compressive properties of mouse articular cartilage determined in a novel micro-indentation test method and biphasic finite element model, Trans. ASME, J. Biomech. Eng. (USA), vol. 128 no. 5 (2006), pp. 766 - 71 [1.2246237]  [abs]
  3. Betre, Helawe and Liu, Wenge and Zalutsky, Michael R. and Chilkoti, Ashutosh and Kraus, Virginia B. and Setton, Lori A., A thermally responsive biopolymer for intra-articular drug delivery, Journal of Controlled Release, vol. 115 no. 2 (2006), pp. 175 - 182 [022]  [abs]
  4. Setton, L.A. and Ong, S.R. and Trabbic-Carlson, K.A. and Nettles, D.L. and Lim, D.W. and Chilkoti, A., Epitope tagging for tracking elastin-like polypeptides, Biomaterials (UK), vol. 27 no. 9 (2006), pp. 1930 - 5 [018]  [abs]
  5. Setton, L.A. and Betre, H. and Ong, S.R. and Guilak, F. and Chilkoti, A. and Fermor, B., Chondrocytic differentiation of human adipose-derived adult stem cells in elastin-like polypeptide, Biomaterials (UK), vol. 27 no. 1 (2006), pp. 91 - 9 [071]  [abs]
  6. Boyd, L.M. and Richardson, W.J. and Chen, J. and Kraus, V.B. and Tewari, A. and Setton, L.A., Osmolarity regulates gene expression in intervertebral disc cells determined by gene array and real-time quantitative RT-PCR, Ann. Biomed. Eng. (USA), vol. 33 no. 8 (2005), pp. 1071 - 7 [s10439-005-5775-y]  [abs]
  7. Gilchrist, C.L. and Xia, J.Q. and Setton, L.A. and Hsu, E.W., High-resolution determination of soft tissue deformations using MRI and first-order texture correlation, IEEE Trans. Med. Imaging (USA), vol. 23 no. 5 (2004), pp. 546 - 53 [TMI.2004.825616]  [abs]
  8. Nettles, D.L. and Vail, T.P. and Morgan, M.T. and Grinstaff, M.W. and Setton, L.A., Photocrosslinkable hyaluronan as a scaffold for articular cartilage repair, Ann. Biomed. Eng. (USA), vol. 32 no. 3 (2004), pp. 391 - 7 [94]  [abs]
  9. Upton, Maureen L. and Chen, Jun and Guilak, Farshid and Setton, Lori A., Differential effects of static and dynamic compression on meniscal cell gene expression, Journal of Orthopaedic Research, vol. 21 no. 6 (2003), pp. 963 - 969 [S0736-0266(03)00063-9]  [abs]
  10. Baer, A.E. and Laursen, T.A. and Guilak, F. and Setton, L.A., The micromechanical environment of intervertebral disc cells determined by a finite deformation, anisotropic, and biphasic finite element model, Trans. ASME, J. Biomech. Eng. (USA), vol. 125 no. 1 (2003), pp. 1 - 11 [1.1532790]  [abs]


Duke University * Pratt * CBTE * Reload * Login