Publications [#188655] of Virginia B Kraus

Papers Published

  1. AE Denoble, KM Huffman, TV Stabler, SJ Kelly, MS Hershfield, GE McDaniel, RE Coleman, VB Kraus, Uric acid is a danger signal of increasing risk for osteoarthritis through inflammasome activation., Proceedings of the National Academy of Sciences of the United States of America, vol. 108 no. 5 (February, 2011), pp. 2088-93, ISSN 1091-6490
    (last updated on 2011/03/23)

    Abstract:
    Uric acid (UA) is known to activate the NLRP3 (Nacht, leucine-rich repeat and pyrin domain containing protein 3) inflammasome. When activated, the NLRP3 (also known as NALP3) inflammasome leads to the production of IL-18 and IL-1β. In this cohort of subjects with knee osteoarthritis (OA), synovial fluid uric acid was strongly correlated with synovial fluid IL-18 and IL-1β. Synovial fluid uric acid and IL-18 were strongly and positively associated with OA severity as measured by both radiograph and bone scintigraphy, and synovial fluid IL-1β was associated with OA severity but only by radiograph. Furthermore, synovial fluid IL-18 was associated with a 3-y change in OA severity, on the basis of the radiograph. We conclude that synovial fluid uric acid is a marker of knee OA severity. The correlation of synovial fluid uric acid with the two cytokines (IL-18 and IL-1β) known to be produced by uric acid-activated inflammasomes and the association of synovial fluid IL-18 with OA progression, lend strong support to the potential involvement of the innate immune system in OA pathology and OA progression.

    Keywords:
    Aged • Carrier Proteins • Cohort Studies • Female • Humans • Interleukin-1 • Interleukin-18 • Knee • Male • Middle Aged • Osteoarthritis • Risk Factors • Severity of Illness Index • Uric Acid • biosynthesis • blood • blood* • genetics • immunology • pathology*