- Pistol, C. and Dwyer, C., Scalable, low-cost, hierarchical assembly of programmable DNA nanostructures,
Nanotechnology (UK), vol. 18 no. 12
pp. 4 pp. -  .
(last updated on 2007/04/17)
We demonstrate a method for the assembly of fully programmable, large molecular weight DNA complexes. The method leverages sticky-end re-use in a hierarchical fashion to reduce the cost of fabrication by building larger complexes from smaller precursors. We have explored the use of controlled non-specific and specific binding between sticky-ends and demonstrate their use in hierarchical assembly. We conclude that it is feasible to scale this method beyond our demonstration of a fully programmable 8960 kD molecular weight 8 × 8 DNA grid for potential application to complex nanoscale system fabrication
atomic force microscopy;DNA;nanotechnology;self-assembly;