Amanda Hargrove, Professor of Chemistry

Contact Info:

Office Location:	3219 FFSC
Office Phone:	(919) 660-1522
Email Address:

Teaching (Spring 2024):

• CHEM 81S.01, INTRO RESEARCH IN CHM Synopsis

  FFSC 1251, Tu 01:25 PM-03:55 PM

Education:

Ph.D.	University of Texas, Austin	2010
B.S.	Trinity University	2004

Research Interests:

The Hargrove lab harnesses the unique properties of small organic molecules to study the structure, function and therapeutic potential of long noncoding RNAs (lncRNAs). The discovery of these fascinating biomolecules has caused a paradigm shift in molecular biology and speculation as to their role as the master drivers of diseases such as cancer. At the same time very little is known about their structure and function, leading some to call the field a veritable “wild West.” Small molecules are the perfect tools for such exploration, and the Hargrove lab works at the interface of chemistry and biology, employing methods ranging from RNA-targeted small molecule synthesis and array-based pattern recognition to studies of the molecular and cellular biology of nucleic acids. Collaborations with the Department of Biology as well as colleagues in the School of Medicine ensure that these tools are applied to the most important unsolved problems in the fundamental biology and disease-related actions of long noncoding RNAs.

Keywords:

Chemical biology • Molecular recognition • Muser Mentor • RNA

Current Ph.D. Students  

• Brittany S. Morgan  
• Christopher Eubanks  

Recent Publications   (More Publications)

1. Bailey, MA; Martyr, JG; Hargrove, AE; Fitzgerald, MC, Stability-Based Proteomics for Investigation of Structured RNA-Protein Interactions., Analytical chemistry (February, 2024) [doi]  [abs]
2. Hymon, D; Martins, J; Richter, C; Sreeramulu, S; Wacker, A; Ferner, J; Patwardhan, NN; Hargrove, AE; Schwalbe, H, NMR ¹H,¹⁹F-based screening of the four stem-looped structure 5_SL1-SL4 located in the 5'-untranslated region of SARS-CoV 2 RNA., RSC medicinal chemistry, vol. 15 no. 1 (January, 2024), pp. 165-177, Royal Society of Chemistry (RSC) [doi]  [abs]
3. Vögele, J; Hymon, D; Martins, J; Ferner, J; Jonker, HRA; Hargrove, AE; Weigand, JE; Wacker, A; Schwalbe, H; Wöhnert, J; Duchardt-Ferner, E, High-resolution structure of stem-loop 4 from the 5'-UTR of SARS-CoV-2 solved by solution state NMR., Nucleic acids research, vol. 51 no. 20 (November, 2023), pp. 11318-11331 [doi]  [abs]
4. Bagnolini, G; Luu, TB; Hargrove, AE, Recognizing the power of machine learning and other computational methods to accelerate progress in small molecule targeting of RNA., RNA (New York, N.Y.), vol. 29 no. 4 (April, 2023), pp. 473-488, Cold Spring Harbor Laboratory [doi]  [abs]
5. Davila-Calderon, J; Li, M-L; Penumutchu, SR; Haddad, C; Malcolm, L; Hargrove, AE; Brewer, G; Tolbert, BS, Enterovirus Evolution Reveals the Mechanism of an RNA-Targeted Antiviral and Determinants of Viral Replication, in Cold Spring Harbor Laboratory, vol. 10 no. 7 (February, 2023), pp. eadg3060, American Association for the Advancement of Science (AAAS) [doi]  [abs]