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Pratt School of Engineering
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Publications [#191212] of Aimee K Zaas

Papers Published

  1. WJ Steinbach, DK Benjamin Jr, SA Trasi, JL Miller, WA Schell, AK Zaas, WM Foster, JR Perfect, Value of an inhalational model of invasive aspergillosis., Medical mycology : official publication of the International Society for Human and Animal Mycology, vol. 42 no. 5 (October, 2004), pp. 417-25, ISSN 1369-3786
    (last updated on 2011/05/02)

    Animal models of invasive aspergillosis have been used for virulence studies and antifungal efficacy evaluations but results have been inconsistent. In an attempt to reproduce human infection, many Aspergillus animal models have utilized a 'pulmonary route' for delivery of conidia, largely through intranasal instillation. However, several radiolabeled particle studies have shown that aerosol delivery is preferable to intranasal instillation to create a more homogenous delivery to the lungs. We hypothesized that an inhalational model would be more robust for studies of invasive aspergillosis pathogenesis and antifungal therapy. We developed an inhalational model of Aspergillus fumigatus infection using a Hinners inhalation chamber and demonstrated by quantitative polymerase chain reaction that this new inhalational model creates a more homogenous murine pneumonia, facilitating analysis of mutant strains and treatment regimens.

    Administration, Inhalation • Animals • Aspergillosis* • Aspergillus fumigatus • Disease Models, Animal* • Humans • Lung • Lung Diseases, Fungal* • Male • Mice • drug effects • drug therapy • microbiology • pathogenicity* • pathology

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