Publications [#260869] of Ashutosh Chilkoti

Papers Published

1. Hoffman, AS; Stayton, PS; Shimoboji, T; Chen, G; Ding, Z; Chilkoti, A; Long, C; Miura, M; Chen, J; Park, T; Monji, N; Cole, CA; Harris, JM; Nakamae, K, Conjugates of Stimuli-Responsive Polymers and Biomolecules: Random and Site-Specific Conjugates of Temperature-Sensitive Polymers and Proteins, Macromolecular Symposia, vol. 118 no. 1 (January, 1997), pp. 553-562, WILEY [doi]
   (last updated on 2024/04/23)

   Abstract:
   Intelligent polymers exhibit sharp, reversible phase changes in response to small changes in environmental conditions. For example, a small temperature change can cause a sharp precipitation or gelation of a smart polymer solution. Conjugation of these unusual polymers to biomolecules such as enzymes, ligands, lipids, and drugs can lead to many new and exciting applications in medicine and biotechnology. (1-4) This presentation reviews the principles, methodolgies and applications of these "smart" polymer-biomolecule systems, with special focus on temperature-sensitive polymer-protein conjugates.