Publications [#328080] of Ashutosh Chilkoti

Chapter in Book

1. Nusz, G; Chilkoti, A, Individual plasmonic nanostructures as label free biosensors, in Nanoplasmonic Sensors (January, 2012), pp. 105-126, Springer New York, ISBN 9781461439325 [doi]
   (last updated on 2024/04/19)

   Abstract:
   This chapter reviews our work and that of other groups in the use of individual plasmonic nanostructures that are presented by a substrate for the labelfree detection of biomolecular binding events. This class of single particle nanosensors is based on the local surface plasmon resonance (LSPR) behavior of noble metal nanostructures that enables optical transduction of binding events at their surface into an optical signal [1-5]. The LSPR peak location and intensity are sensitive to the local refractive index surrounding the nanoparticle, which is altered by the binding of biomolecular targets to receptor-functionalized nanostructures, and forms the basis of their utility as label-free biosensors.