Publications [#134198] of Mark W. Dewhirst

Papers Published

1. DM Prescott, TV Samulski, MW Dewhirst, RL Page, DE Thrall, RK Dodge, JR Oleson, Use of nitroprusside to increase tissue temperature during local hyperthermia in normal and tumor-bearing dogs., International journal of radiation oncology, biology, physics, UNITED STATES, vol. 23 no. 2 (1992), pp. 377-85, ISSN 0360-3016
   (last updated on 2004/03/30)

   Abstract:
   The present study investigates the effects of nitroprusside, a potent vasodilating agent, on tissue temperature during local hyperthermia in five normal and five tumor-bearing dogs. Caudal thigh muscles were heated in normal dogs and muscle temperatures were recorded during hyperthermia. Tumor-bearing dogs received two hyperthermia treatments during a course of radiation therapy. Temperatures were recorded in tumor and surrounding normal tissues. Mean arterial pressure was decreased by approximately 40-45% during nitroprusside infusion and was associated with a compensatory increase in heart rate and increases in tissue temperature. In normal dogs, muscle temperatures increased an average of 1.7 degrees C with nitroprusside administration. When nitroprusside was administered at the beginning of local hyperthermia to induce step-down heating, approximately 48% of the measured positions in caudal thigh muscle achieved a temperature greater than or equal to 43 degrees C, sufficient to induce step-down heating, during the hyperthermia episode. In tumor-bearing dogs, there was a significant increase in tumor and normal tissue temperatures during nitroprusside administration. Estimated T90 and T50 descriptors increased by 0.9 degrees C and 1.6 degrees C, respectively, for tumor tissue and by 0.4 degrees C and 1.2 degrees C, respectively, for normal tissue. Despite the increase in normal tissue temperatures no toxicity was observed in these dogs. Nitroprusside may be a useful agent for manipulation of tumor temperatures during the entire hyperthermia treatment or for a short time period at the initiation of treatment to induce step-down heating.

   Keywords:
   Animals • Body Temperature • Combined Modality Therapy • Dogs • Hyperthermia, Induced • Neoplasms, Experimental • Nitroprusside • Stimulation, Chemical • drug effects* • drug therapy • methods* • therapeutic use* • therapy*