Publications [#168886] of Mark W. Dewhirst

Papers Published

1. DE Thrall, SM Larue, AF Pruitt, B Case, MW Dewhirst, Changes in tumour oxygenation during fractionated hyperthermia and radiation therapy in spontaneous canine sarcomas., International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, vol. 22 no. 5 (August, 2006), pp. 365-73, ISSN 0265-6736 [doi]
   (last updated on 2013/05/16)

   Abstract:
   Tumour oxygenation was measured in seven canine soft tissue sarcomas being treated with a fractionated course of radiation and hyperthermia. Measurements obtained during treatment were compared to pre-treatment measurements. The most important finding was an increase in oxygenation in tumours with low pre-treatment oxygenation that persisted throughout treatment. This is an advantageous hyperthermia effect as it may lead to increased radiation cell killing at each fraction. In other tumours, potentially less advantageous changes in oxygenation may be hyperthermia fractionation related and this deserves further investigation.

   Keywords:
   Animals • Cell Hypoxia • Combined Modality Therapy • Dog Diseases • Dogs • Hyperthermia, Induced • Oxygen • Sarcoma • analysis* • metabolism • methods • physiology • radiation effects* • therapy • therapy* • veterinary • veterinary*