| Publications [#168971] of Mark W. Dewhirst
Papers Published
- EL Jones, JR Oleson, LR Prosnitz, TV Samulski, Z Vujaskovic, D Yu, LL Sanders, MW Dewhirst, Randomized trial of hyperthermia and radiation for superficial tumors.,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, vol. 23 no. 13
(May, 2005),
pp. 3079-85, ISSN 0732-183X [doi]
(last updated on 2013/05/16)
Abstract: OBJECTIVE: Randomized clinical trials have demonstrated hyperthermia (HT) enhances radiation response. These trials, however, generally lacked rigorous thermal dose prescription and administration. We report the final results of a prospective randomized trial of superficial tumors (= 3 cm depth) comparing radiotherapy versus HT combined with radiotherapy, using the parameter describing the number of cumulative equivalent minutes at 43 degrees C exceeded by 90% of monitored points within the tumor (CEM 43 degrees C T(90)) as a measure of thermal dose. METHODS: This trial was designed to test whether a thermal dose of more than 10 CEM 43 degrees C T(90) results in improved complete response and duration of local control compared with a thermal dose of = 1 CEM 43 degrees C T(90). Patients received a test dose of HT = 1 CEM 43 degrees C T(90) and tumors deemed heatable were randomly assigned to additional HT versus no additional HT. HT was given using microwave spiral strip applicators operating at 433 MHz. RESULTS: One hundred twenty-two patients were enrolled; 109 (89%) were deemed heatable and were randomly assigned. The complete response rate was 66.1% in the HT arm and 42.3% in the no-HT arm. The odds ratio for complete response was 2.7 (95% CI, 1.2 to 5.8; P = .02). Previously irradiated patients had the greatest incremental gain in complete response: 23.5% in the no-HT arm versus 68.2% in the HT arm. No overall survival benefit was seen. CONCLUSIONS: Adjuvant hyperthermia with a thermal dose more than 10 CEM 43 degrees C T(90) confers a significant local control benefit in patients with superficial tumors receiving radiation therapy.
Keywords: Adolescent • Adult • Aged • Aged, 80 and over • Breast Neoplasms • Combined Modality Therapy • Female • Head and Neck Neoplasms • Humans • Hyperthermia, Induced* • Male • Melanoma • Middle Aged • Prospective Studies • Skin Neoplasms • Survival Analysis • Treatment Outcome • radiotherapy* • therapy*
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