Publications [#63269] of Mark W. Dewhirst

Papers Published

1. Rine, G.P. and Dewhirst, M.W. and Cobb, E.D. and Clegg, S.T. and Coleman, E.N. and Samulski, T.V. and Wallen, C.A., Feasibility of estimating the temperature distribution in a tumor heated by a waveguide applicator, Int. J. Radiat. Oncol. Biol. Phys. (UK), vol. 23 no. 5 (1992), pp. 1009 - 19
   (last updated on 2007/04/14)

   Abstract:
   The feasibility of using a 2-dimensional (2D) modeling approach for retrospectively describing complete temperature distributions in the midplane of a tumor during a clinical hyperthermia treatment was tested. An experimental treatment, using a 915-MHz waveguide applicator to heat a large melanoma in a dog, was modeled. Detailed measurement of temperatures were made during the treatment. The steady-state blood flow distribution at the midplane was imaged by positron emission tomography (PET), and these data were used to prescribe the modeled perfusion pattern. A 2D finite element method (FEM) was used to approximate the solution to Maxwell's Equations to obtain the specific absorption rate (SAR) distribution. The blood-flow estimates, assumed material properties, SAR distribution, and temperature boundary conditions were then used with the same mesh in a second FEM program to obtain a solution to the bioheat transfer equation. Optimizations were performed independently for three subsets of the measured temperature data to assess the sensitivity of the predicted temperature field to the number of measurements. The calculated temperature distributions that resulted were similar to each other, and the predicted temperatures at the sensor points excluded from these optimizations were in reasonable agreement with the measurements

   Keywords:
   biothermics;physiological models;radiation therapy;radiofrequency heating;temperature measurement;