Office Location: | B120 LSRC |
Office Phone: | (919) 660-1506, (919) 681-5161 |
Email Address: | |
Web Page: | http://www.chem.duke.edu/%7Etoone/labgroup/ |
Ph.D. | University of Toronto (Canada) | 1988 |
M.S. | University of Toronto (Canada) | 1985 |
B.S. | University of Guelph (Canada) | 1983 |
Dr. Toone is a physical organic chemist who studies relationships between structure and activity in the context of biology. Currently active programs exist in biocatalysis/applied enzymology, ligand binding and the activity of water, and the synthesis of novel donors of nitric oxide. The study of these problems makes use of synthetic organic chemistry, traditional enzymology, isothermal titration microcalorimetry, and the techniques of directed evolution.