Research Interests for Eric J. Toone

Dr. Toone is a physical organic chemist who studies relationships between structure and activity in the context of biology. Currently active programs exist in biocatalysis/applied enzymology, ligand binding and the activity of water, and the synthesis of novel donors of nitric oxide. The study of these problems makes use of synthetic organic chemistry, traditional enzymology, isothermal titration microcalorimetry, and the techniques of directed evolution.

Recent Publications

1. Arnold, JJ; Choksi, Y; Chen, X; Shimazaki, A; Hatten, J; Toone, EJ; Epstein, DL; Challa, P, Eyedrops Containing SA9000 Prodrugs Result in Sustained Reductions in Intraocular Pressure in Rabbits, J. Ocul. Pharmacol. Ther., no. 25 (3) (2009), pp. 179-186
2. Gao, W; Liu, W; Mackay, JA; Zalutsky, MR; Toone, EJ; Chilkoti, A., In situ Growth of a Stoichiometric PEG-like Conjugate at a Protein’s N-terminus with Significantly Improved Pharmacokinetics, Proc. Natl. Acad. Sci. USA no. 36 (2009), pp. 15231-15236
3. Wilfong, EM; Locklear, U; Toone, EJ., A Single Step Purification for Autolytic Zinc Proteinases, Bioorg. Med. Chem. Lett (Accepted, 2009)
4. Shestopalov, A. L.; Clark, R. L.; Toone, E. J., Catalytic Microcontact Printing on Chemically Functionalized H-Terminated Silicon, Langmuir (Accepted, 2009)
5. Shestopalov, A. L.; Clark, R. L.; Toone, E. J., Inkless Microcontact Printing on SAMs of Boc- and TBS-Protected Thiols on Gold, Nano Lett. (Accepted, 2009)