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Pratt School of Engineering
Duke University

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Bernard M Fischer, Associate Professor of Pediatrics

Contact Info:
Office Location:  356 Sands Building
Office Phone:  (919) 684-6282, (919) 660-0258
Email Address: send me a message
Web Page:  http://faculty.duhs.duke.edu/faculty/info?pid=4235

Teaching (Spring 2017):

  • HOUSECS 59.04, HOUSE COURSE (SP TOP) Synopsis
    SEE INSTRU, Tu 07:00 PM-09:00 PM
Education:

Ph.D.North Carolina State University1997
D.V.M.North Carolina State University1988

Representative Publications   (More Publications)

  1. ML Meyer, EN Potts-Kant, AJ Ghio, BM Fischer, WM Foster, JA Voynow, NAD(P)H quinone oxidoreductase 1 regulates neutrophil elastase-induced mucous cell metaplasia., American journal of physiology. Lung cellular and molecular physiology, vol. 303 no. 3 (August, 2012), pp. L181-8, ISSN 1522-1504 [doi]  [abs]
  2. BM Fischer, E Pavlisko, JA Voynow, Pathogenic triad in COPD: oxidative stress, protease-antiprotease imbalance, and inflammation., International journal of chronic obstructive pulmonary disease, vol. 6 (2011), pp. 413-21, ISSN 1178-2005 [doi]  [abs]
  3. WM Foster, KB Adler, AL Crews, EN Potts, BM Fischer, JA Voynow, MARCKS-related peptide modulates in vivo the secretion of airway Muc5ac., American journal of physiology. Lung cellular and molecular physiology, vol. 299 no. 3 (September, 2010), pp. L345-52, ISSN 1522-1504 [doi]  [abs]
  4. BM Fischer, DA Domowicz, S Zheng, JL Carter, NG McElvaney, C Taggart, JR Lehmann, JA Voynow, AJ Ghio, Neutrophil elastase increases airway epithelial nonheme iron levels., Clinical and translational science, vol. 2 no. 5 (October, 2009), pp. 333-9, ISSN 1752-8062 [doi]  [abs]
  5. JA Voynow, BM Fischer, S Zheng, EN Potts, AR Grover, AK Jaiswal, AJ Ghio, WM Foster, NAD(P)H quinone oxidoreductase 1 is essential for ozone-induced oxidative stress in mice and humans., American journal of respiratory cell and molecular biology, vol. 41 no. 1 (July, 2009), pp. 107-13, ISSN 1535-4989 [doi]  [abs]
  6. Auten RL, Potts EN, Mason SN, Fischer B, Huang Y, Foster WM. Maternal exposure to particulate matter increases postnatal ozone-induced airway hyperreactivity in juvenile mice. Am J Respir Crit Care Med. 2009 Dec 15; 180 (12) :1218-26. PubMed PMID:19762564;
  7. JA Voynow, BM Fischer, S Zheng, Proteases and cystic fibrosis., The international journal of biochemistry & cell biology, vol. 40 no. 6-7 (2008), pp. 1238-45, ISSN 1357-2725 [doi]  [abs]
  8. BM Fischer, S Zheng, R Fan, JA Voynow, Neutrophil elastase inhibition of cell cycle progression in airway epithelial cells in vitro is mediated by p27kip1., American journal of physiology. Lung cellular and molecular physiology, vol. 293 no. 3 (September, 2007), pp. L762-8, ISSN 1040-0605 [doi]  [abs]
  9. S Zheng, AS Byrd, BM Fischer, AR Grover, AJ Ghio, JA Voynow, Regulation of MUC5AC expression by NAD(P)H:quinone oxidoreductase 1., Free radical biology & medicine, vol. 42 no. 9 (May, 2007), pp. 1398-408, ISSN 0891-5849 [doi]  [abs]
  10. JA Voynow, BM Fischer, BC Roberts, AD Proia, Basal-like cells constitute the proliferating cell population in cystic fibrosis airways., American journal of respiratory and critical care medicine, vol. 172 no. 8 (October, 2005), pp. 1013-8, ISSN 1073-449X [doi]  [abs]
  11. BM Fischer, JG Cuellar, AS Byrd, AB Rice, JC Bonner, LD Martin, JA Voynow, ErbB2 activity is required for airway epithelial repair following neutrophil elastase exposure., FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol. 19 no. 10 (August, 2005), pp. 1374-6, ISSN 1530-6860 [doi]  [abs]
  12. JA Voynow, BM Fischer, DE Malarkey, LH Burch, T Wong, M Longphre, SB Ho, WM Foster, Neutrophil elastase induces mucus cell metaplasia in mouse lung., American journal of physiology. Lung cellular and molecular physiology, vol. 287 no. 6 (December, 2004), pp. L1293-302, ISSN 1040-0605 [doi]  [abs]
  13. TM Krunkosky, LD Martin, BM Fischer, JA Voynow, KB Adler, Effects of TNFalpha on expression of ICAM-1 in human airway epithelial cells in vitro: oxidant-mediated pathways and transcription factors., Free radical biology & medicine, vol. 35 no. 9 (November, 2003), pp. 1158-67, ISSN 0891-5849  [abs]
  14. BM Fischer, JG Cuellar, ML Diehl, AM deFreytas, J Zhang, KL Carraway, JA Voynow, Neutrophil elastase increases MUC4 expression in normal human bronchial epithelial cells., American journal of physiology. Lung cellular and molecular physiology, vol. 284 no. 4 (April, 2003), pp. L671-9, ISSN 1040-0605 [doi]  [abs]
  15. BM Fischer, JA Voynow, Neutrophil elastase induces MUC5AC gene expression in airway epithelium via a pathway involving reactive oxygen species., American journal of respiratory cell and molecular biology, vol. 26 no. 4 (April, 2002), pp. 447-52, ISSN 1044-1549 [doi]  [abs]
  16. TM Krunkosky, BM Fischer, LD Martin, N Jones, NJ Akley, KB Adler, Effects of TNF-alpha on expression of ICAM-1 in human airway epithelial cells in vitro. Signaling pathways controlling surface and gene expression., American journal of respiratory cell and molecular biology, vol. 22 no. 6 (June, 2000), pp. 685-92, ISSN 1044-1549 [doi]  [abs]
  17. Fischer BM, Voynow JA. Neutrophil elastase induces MUC5AC expression by an oxidant-dependent mechanism. Chest 117(May Supplement): 371S-320S, 2000.
  18. Voynow JA, Fischer BM. Regulation of repiratory mucin gene expression by neutrophil elastase. In: Salathe, M (ED). Cilia, Mucus, and Mucociliary Interactions, Marcel Dekker, Inc., New York, NY, In Press, 2000.
  19. JA Voynow, LR Young, Y Wang, T Horger, MC Rose, BM Fischer, Neutrophil elastase increases MUC5AC mRNA and protein expression in respiratory epithelial cells., The American journal of physiology, vol. 276 no. 5 Pt 1 (May, 1999), pp. L835-43, ISSN 0002-9513  [abs]
  20. BM Fischer, LG Rochelle, JA Voynow, NJ Akley, KB Adler, Tumor necrosis factor-alpha stimulates mucin secretion and cyclic GMP production by guinea pig tracheal epithelial cells in vitro., American journal of respiratory cell and molecular biology, vol. 20 no. 3 (March, 1999), pp. 413-22, ISSN 1044-1549 [doi]  [abs]
  21. Voynow JA, Diehl ML, Fischer BM. Neutrophil elastase increases MUC4 gene expression by enhancing mRNA stability. Pediatric Pulmonology Suppl 19:257, 1999.
  22. LG Rochelle, BM Fischer, KB Adler, Concurrent production of reactive oxygen and nitrogen species by airway epithelial cells in vitro., Free radical biology & medicine, vol. 24 no. 5 (March, 1998), pp. 863-8, ISSN 0891-5849  [abs]
  23. Adler KB, Fischer BM, Martin LD, Voynow JA. Effects of inflammatory mediators and drugs on mucus secretion and mucociliary function. Res. Immunol. 149: In Press, 1998.
  24. Fischer BM, Li CM, Li HF, Choe NH, Wright DT, Rochelle LG, Adler KB. Intracellular regulation of mucin secretion in airway epithelial cells in vitro. In: Baum GL [ED]. International Congress on Cilia, Mucus and Mucociliary Interactions, Marcel Dekker, Inc., New York, NY. pp. 143-151, 1998.
  25. Fischer BM, Scott S, Voynow JA. Reactive oxygen species mediate neutrophil elastase induced MUC5AC expression. Free Rad Biol Med 25 (Suppl 1):S49, 1998.
  26. Fischer BM, Voynow JA. Neutrophil elastase induces MUC5AC mRNA expression by an oxidant-dependent mechanism. Pediatric Pulmonology Suppl 17:286, 1998.
  27. Krunkosky TM, Fischer BM, Dodam J, Adler KB. Mechanisms of TNFa induced signaling in airway epithelium. Am J Resp Crit Care Med. 157(3): A198, 1998.
  28. Voynow JA, Horger T, Fischer BM, Rose MC. Neutrophil elastase treatment increases MUC5/5AC glycoprotein levels in A549 cell lysates. Am J Resp Crit Care Med 157(3): A728, 1998.
  29. LD Martin, TM Krunkosky, JA Dye, BM Fischer, NF Jiang, LG Rochelle, NJ Akley, KL Dreher, KB Adler, The role of reactive oxygen and nitrogen species in the response of airway epithelium to particulates., Environmental health perspectives, vol. 105 Suppl 5 (September, 1997), pp. 1301-7, ISSN 0091-6765  [abs]
  30. LD Martin, LG Rochelle, BM Fischer, TM Krunkosky, KB Adler, Airway epithelium as an effector of inflammation: molecular regulation of secondary mediators., The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology, vol. 10 no. 9 (September, 1997), pp. 2139-46, ISSN 0903-1936  [abs]
  31. Adler KB, Li C, Li H, Choe NH, Fischer BM. Intracellular regulation of mucin secretion. Presented at the International Congress on Cilia, Mucus and Mucociliary Interactions. 1997.
  32. Chitano P, Fischer BM, Murphy TM. Maturational changes in the pattern of smooth muscle relaxation in guinea pig trachealis are not associated with changes of basal cyclic nucleotide content. Am J Resp Crit Care Med. 155:A56, 1997.
  33. Cohn LA, Fischer BM, Krunkosky TM, Wright DT, and Adler KB. Airway epithelial cells in Asthma. In: Kay, AB [ED]. Allergy and Allergic Diseases, Blackwell Science, Ltd., Oxford, U.K. pages 263-283, 1997.
  34. Fischer BM, Li C-M, Li H-F, Choe N-H, Wright DT, Rochelle LG, and Adler KB. Intracellular regulation of mucin secretion in airway epithelial cells in vitro. In: Baum GL [ED]. International Congress on Cilia, Mucus and Mucociliary Interactions, Marcel Dekker, Inc., New York, NY. In Press, 1997.
  35. Krunkosky TM, Martin LD, Fischer BM, Adler KB. Mechanisms of TNFa induced ICAM-1 expression in airway epithelium. Am J Resp Crit Care Med. 155: A207, 1997.
  36. Martin LD, Krunkosky TM, Dye JA, Fischer BM, Jiang NF, Rochelle LG, Akley NJ, Dreher KL, Adler KB. The Role of Reactive Oxygen and Nitrogen Species in theResponse of Airway Epithelium to Particulates Environ Health Perspect. 1997 Sep;105S(Suppl 5):1301-7.
  37. Rochelle LG, Fischer BM, Boehm KA, Akley NJ, and Adler KB. Inflammatory mediators increase intracellular oxygen and nitrogen species (ROS/RNS) in airway epithelial cells. Am J Resp Crit Care Med. 155: A437, 1997.
  38. Wright DT, Fischer BM, Li C, Yagaloff KA, and Adler KB. Interactions between oxidant gases and airway epithelium: In vitro-In vivo correlations. In: Dungworth DK, Adler KB, Harris CC, Plopper CG [ED]. Correlations between in vitro and in vivo investigations in inhalation toxicology. ILSI Press, Washington, D.C., pages 217-229, 1997.
  39. DT Wright, BM Fischer, C Li, LG Rochelle, NJ Akley, KB Adler, Oxidant stress stimulates mucin secretion and PLC in airway epithelium via a nitric oxide-dependent mechanism., The American journal of physiology, vol. 271 no. 5 Pt 1 (November, 1996), pp. L854-61, ISSN 0002-9513  [abs]
  40. TM Krunkosky, BM Fischer, NJ Akley, KB Adler, Tumor necrosis factor alpha (TNF alpha)-induced ICAM-1 surface expression in airway epithelial cells in vitro: possible signal transduction mechanisms., Annals of the New York Academy of Sciences, vol. 796 (October, 1996), pp. 30-7, ISSN 0077-8923  [abs]
  41. LG Rochelle, BM Fischer, TM Krunkosky, DT Wright, KB Adler, Environmental toxins induce intracellular responses of airway epithelium through reactive species of oxygen and nitrogen. Roger S. Mitchell Lecture., Chest, vol. 109 no. 3 Suppl (March, 1996), pp. 35S-39S, ISSN 0012-3692
  42. Adler KB, Krunckosky TM, Fischer BM, Rochelle LG, Martin LD, Dreher KL, Jiang NF, Janice Dye. Role of reactive oxygen and nitrogen species in the response of airway epithelium to particulates. Sixth International Meeting on the Toxicology of Natural and Man-made Fibrous and Non-fibrous Particles. 1966.
  43. Adler KB, Wright DT, Fischer BM. Reactive oxygen species provoke secretion of mucin and activate phospholipase C in airway epithelial cells via a mechanism dependent on nitric oxide and hydroxyl free radical. Keystone Symposium on Molecular and Cellular Biology - Oxidant Stress: From molecules to man. 1996.
  44. Fischer BM, Rochelle LG, Akley NJ, and Adler KB. Tumor necrosis factor-alpha (TNFa) induced mucin secretion: Dependence on nitric oxide (NO) and cyclic GMP. Am J Resp Crit Care Med. 153(4): A538, 1996.
  45. Krunkosky TM, Fischer BM, Martin LD, Adler KB. Tumor necrosis factor alpha (TNFa) provokes expression of inercellular adhesion molecule-1 (ICAM-1) on human bronchial epithelial cells in primary culture. Am J Resp Crit Care Med. 153(4): A27, 1996.
  46. Wright DT, Fischer BM, Li C-M, Rochelle LG, Akley NJ & Adler KB. Oxidant Stress stimulates mucin secretion and OLC in airways epithelium via nitric oxide-dependent mechanism. Amer J Physiol 271 (Lung Cell Mol Physiol 15): L854d-L861, 1996.
  47. KB Adler, BM Fischer, H Li, NH Choe, DT Wright, Hypersecretion of mucin in response to inflammatory mediators by guinea pig tracheal epithelial cells in vitro is blocked by inhibition of nitric oxide synthase., American journal of respiratory cell and molecular biology, vol. 13 no. 5 (November, 1995), pp. 526-30, ISSN 1044-1549 [doi]  [abs]
  48. BM Fischer, M Kreiselmeyer, J Schlegel, S Schadmand, S Iversen, HJ Rupprecht, J Lorenz, R Ferlinz, [Lung function in chronic persistent pulmonary embolism]., Pneumologie (Stuttgart, Germany), vol. 49 no. 4 (April, 1995), pp. 273-6, ISSN 0934-8387  [abs]
  49. BM Fischer, TM Krunkosky, DT Wright, M Dolan-O'Keefe, KB Adler, Tumor necrosis factor-alpha (TNF-alpha) stimulates mucin secretion and gene expression in airway epithelium in vitro., Chest, vol. 107 no. 3 Suppl (March, 1995), pp. 133S-135S, ISSN 0012-3692
  50. Fischer BM, Wright DT, Li H, Li C-M, Cohn LA, Akley NJ, and Adler KB. Endogenously-generated nitric oxide (NO) may be a key signaling molecule in hypersecretion of mucin by guinea pig tracheal epithelial (GPTE) cells in vitro. Am. J. Respir. Crit. Care Med. 151(4): A337, 1995.
  51. Krunkosky TM, Fischer BM, Wright DT, Akley NJ, and Adler KB. Effects of tumor necrosis factor alpha (TNFa) on expression of ICAM-1 and inflammation-associated genes in airway epithelial cells in vitro. Am. J. Respir. Crit. Care Med. 151(4): A366, 1995.
  52. Rochelle LG, Fischer BM, Wright DT, Li H-F, Choe N-H, Adler KB. NO may act as a critical signalliing molecule controlling mucin secretion by airway epithelial cells. 4th International Meeting of the Biology of Nitric Oxide, 1995.
  53. Wright DT, Li C-M, Fischer BM, Akley NJ, and Adler KB. Reactive nitrogen species (RNS) stimulate secretion of mucin by primary cultures of guinea pig tracheal epithelial (GPTE) cells. Am. J. Respir. Crit. Care Med. 151(4): A337, 1995.
  54. KB Adler, BM Fischer, DT Wright, LA Cohn, S Becker, Interactions between respiratory epithelial cells and cytokines: relationships to lung inflammation., Annals of the New York Academy of Sciences, vol. 725 (May, 1994), pp. 128-45, ISSN 0077-8923  [abs]
  55. Adler KB, Fischer BM, Wright DT, Dolan-O'Keefe M. Effects of Tumor necrosis factor alpha (TNFa) on airway epithelial cells in vitro. Proceedings of the 8th International Colloquium on Lung Fibrosis: A3, 1994.
  56. Adler KB, Wright DT, Fischer BM, Cohn LA, Li H, Li C, Choe NH, Akler NJ. Effects of oxidant stress on airway epithelial cells in vitro. FASEB J. 8: A896, 1994.
  57. Wright DT, Akley NJ, Li H, Fischer BM and Adler KB. Reactive Oxidant Species (ROS) activate Phosphoplipase C in Guinea Pig and Human Airway Epithelial Cell In Vitro. Am. J Resp. & Crit. Care Med. 149: A315, 1994.
  58. Wright DT, Cohn LA, Li H, Fischer BM, Li C, Adler KB. Interactions of oxygen radicals with airway epithelium. Environ. Health Perspect., 102 (Suppl. 10): 85-90, 1994.
  59. GS Price, RL Page, BM Fischer, JF Levine, TM Gerig, Efficacy and toxicity of doxorubicin/cyclophosphamide maintenance therapy in dogs with multicentric lymphosarcoma., Journal of veterinary internal medicine / American College of Veterinary Internal Medicine, vol. 5 no. 5 (January, 1992), pp. 259-62, ISSN 0891-6640  [abs]


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