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Publications [#119287] of Bernard M Fischer

Papers Published

  1. GS Price, RL Page, BM Fischer, JF Levine, TM Gerig, Efficacy and toxicity of doxorubicin/cyclophosphamide maintenance therapy in dogs with multicentric lymphosarcoma., Journal of veterinary internal medicine / American College of Veterinary Internal Medicine, vol. 5 no. 5 (January, 1992), pp. 259-62, ISSN 0891-6640
    (last updated on 2013/05/16)

    Abstract:
    Doxorubicin/cyclophosphamide were evaluated as maintenance drugs for dogs with multicentric lymphosarcoma (n = 28). Median remission time of all dogs was 173 days. Remission duration was shorter, however, in dogs with stage IV/V disease, in dogs with pretreatment hypoalbuminemia, and in dogs that had received glucocorticoids before initiation of chemotherapy (P less than 0.04). Nineteen dogs were evaluable for toxicity. Dose-limiting gastrointestinal toxicosis was observed in three dogs, neutropenia was observed in three dogs, and cardiomyopathy was observed in three dogs. The doxorubicin/cyclophosphamide protocol described in this report is safe and effective in treating canine multicentric lymphosarcoma. Clinical stage, pretreatment steroid therapy, and hypoalbuminemia are prognostic factors for response to this protocol.

    Keywords:
    Animals • Antineoplastic Combined Chemotherapy Protocols • Cyclophosphamide • Diarrhea • Dog Diseases • Dogs • Doxorubicin • Female • Heart Diseases • Lymphoma, Non-Hodgkin • Male • Neutropenia • Remission Induction • Vomiting • administration & dosage • adverse effects • chemically induced • drug therapy • drug therapy* • therapeutic use* • veterinary • veterinary*


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