Publications [#132782] of G. Allan Johnson
- JR MacFall, JH Maki, GA Johnson, L Hedlund, H Benveniste, G Copher, Diffusion/microcirculation MRI in the rat brain.,
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, UNITED STATES, vol. 19 no. 2
pp. 305-10, ISSN 0740-3194
(last updated on 2005/08/03)
The CO2 fraction of an anesthetized rat's breathing mixture was changed (from 0 to 10%) to attempt to change the brain microcirculation and observe these changes in diffusion measurements of the neural tissue. Brain apparent diffusion coefficients were measured to be (0.71 +/- 0.01) X 10(-3) mm2/s before sacrifice and (0.39 +/- 0.01) X 10(-3) mm2/s after sacrifice. Multiple diffusion components were observed, consistent with flowing material, but the extra components did not increase with increased CO2. It is proposed that the additional components may be due to extracellular, extravascular water such as CSF.
Animals • Brain • Carbon Dioxide • Cerebrovascular Circulation • Diffusion • Magnetic Resonance Imaging* • Microcirculation • Rats • Rats, Inbred Strains • administration & dosage • anatomy & histology • blood supply • metabolism • pharmacokinetics • physiology*