Publications [#132849] of G. Allan Johnson
- GA Johnson, RR Maronpot, Magnetic resonance microscopy of chemically-induced liver foci.,
Toxicologic pathology, UNITED STATES, vol. 17 no. 4 Pt 1
pp. 613-6, ISSN 0192-6233
(last updated on 2005/08/03)
Magnetic resonance imaging (MRI) is a new imaging technique used in clinical diagnosis. This paper describes extension of the technique to basic research applications--specifically detecting and characterizing chemically-induced liver neoplasms and foci of cellular alteration. Two systems have been built that allow spatial microscopic resolution--more than 100,000 x greater than that of earlier efforts. Use of spin-lattice (T1) and spin-spin (T2) relaxation times permits detailed characterization of the tissue.
Animals • Carcinogenicity Tests • Diet • Female • Liver • Liver Neoplasms, Experimental • Magnetic Resonance Imaging • Rats • Rats, Inbred F344 • chemically induced • pathology* • ultrastructure