Publications [#132877] of G. Allan Johnson

Papers Published

1. H Qiu, LW Hedlund, SL Gewalt, H Benveniste, TM Bare, GA Johnson, Progression of a focal ischemic lesion in rat brain during treatment with a novel glycine/NMDA antagonist: an in vivo three-dimensional diffusion-weighted MR microscopy study., Journal of magnetic resonance imaging : JMRI, UNITED STATES, vol. 7 no. 4 , pp. 739-44, ISSN 1053-1807
   (last updated on 2005/08/03)

   Abstract:
   Stroke was induced in two groups of anesthetized rats by occlusion of the middle cerebral artery (MCA) and ipsilateral common carotid artery. Group 1 (control) received vehicle and group 2 received the glycine N-methyl-D-aspartate (NMDA) antagonist ZD9379. Stroke volume was assessed by three-dimensional diffusion-weighted MR microscopy at 2.5 and 6 hours of MCA occlusion. At 2.5 hours, stroke volumes were identical in the two groups. At 6 hours, stroke volumes had increased by 15% in the control group; in contrast, the treated group showed a 40% reduced stroke volume. Conclusions from this in vivo study were as follows: (a) our technique allows more efficient and accurate measurement of stroke volume with an improvement in resolution over a previous method; (b) the ability to measure stroke volume at multiple time points shows volume change and assessment of time dependency of drug treatment; (c) at 6 hours, the glycine antagonist ZD9379 reduced stroke volume by 40%.

   Keywords:
   Animals • Brain • Brain Ischemia • Female • Image Processing, Computer-Assisted • Magnetic Resonance Imaging • Pyridazines • Quinolines • Rats • Rats, Inbred F344 • Receptors, Glycine • Time Factors • antagonists & inhibitors* • drug therapy* • methods • methods* • pathology • pathology* • therapeutic use*