Publications [#132888] of G. Allan Johnson
- WM Thompson, WC Meyers, M Shaw, M Bates, GA Johnson, LW Hedlund, Gallbladder density and iodine concentration in humans during oral cholecystography. A comparison of iopanoic acid and iopronic acid.,
Investigative radiology, UNITED STATES, vol. 17 no. 6
pp. 621-8, ISSN 0020-9996
(last updated on 2005/08/03)
A comparison of two oral cholecystopaques, iopanoic acid (Telepaque) and iopronic acid (Oravue), was performed using normal volunteers. Using a double-blind crossover design, comparisons were made between the degree of gallbladder opacification and the amount of iodine recovered from the gallbladder. Bile was collected via a double lumen intestinal tube before, during, and after stimulating gallbladder contraction. There were no differences between the two agents in terms of opacification or iodine concentration. Only 19% of the administered dose of either agent was recovered, and the maximum iodine concentration in bile was 10 mg I/ml. The results suggest that this technique has merit for future comparative studies of agents concentrated in the gallbladder.
Administration, Oral • Bile Acids and Salts • Cholecystography* • Clinical Trials • Contrast Media • Double-Blind Method • Gallbladder • Humans • Iodine • Iodobenzenes • Iopanoic Acid • administration & dosage* • analysis