Publications [#132891] of G. Allan Johnson
- HE Möller, MS Chawla, XJ Chen, B Driehuys, LW Hedlund, CT Wheeler, GA Johnson, Magnetic resonance angiography with hyperpolarized 129Xe dissolved in a lipid emulsion.,
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, UNITED STATES, vol. 41 no. 5
pp. 1058-64, ISSN 0740-3194
(last updated on 2005/08/03)
Hyperpolarized (HP) 129Xe can be dissolved in biologically compatible lipid emulsions while maintaining sufficient polarization for in vivo vascular imaging. For xenon in Intralipid 30%, in vitro spectroscopy at 2 T yielded a chemical shift of 197 +/- 1 ppm with reference to xenon gas, a spin-lattice relaxation time T1 = 25.3 +/- 2.1 sec, and a T2* time constant of 37 +/- 5 msec. Angiograms of the abdominal and pelvic veins in the rat obtained with 129Xe MRI after intravenous injection of HP 129Xe/Intralipid 30% into the tail demonstrated signal-to-noise ratios between 8 and 29. An analysis of the inflow effect on time-of-flight images of two segments of the inferior vena cava yielded additional information. The mean blood flow velocity was 34.7 +/- 1.0 mm/sec between the junction of the caudal veins and the kidneys and 13.3 +/- 0.8 mm/sec at the position of the diaphragm. The mean volume flow rates in these segments were 7.2 +/- 3.4 ml/min and 11.0 +/- 2.8 ml/min, respectively. Intravenous delivery of HP 129Xe dissolved in a carrier may lead to novel biomedical applications of laser-polarized gases.
Abdomen • Animals • Artifacts • Blood Flow Velocity • Blood Volume • Contrast Media* • Electron Spin Resonance Spectroscopy • Fat Emulsions, Intravenous • Iliac Vein • Injections, Intravenous • Lasers • Magnetic Resonance Angiography • Magnetic Resonance Spectroscopy • Male • Pelvis • Rats • Renal Veins • Signal Processing, Computer-Assisted • Veins • Vena Cava, Inferior • Xenon Isotopes* • administration & dosage • anatomy & histology • blood supply • diagnostic use* • methods*