Publications [#174214] of G. Allan Johnson
- GA Johnson, KJ Barsuhn, JM McCall, Sulfation of minoxidil by liver sulfotransferase.,
Biochemical pharmacology, vol. 31 no. 18
pp. 2949-54, ISSN 0006-2952
(last updated on 2010/04/30)
The 100,000 g supernatant fraction of rat liver homogenate contains a sulfotransferase activity which catalyzes the sulfation of minoxidil. Synthetic minoxidil N-O sulfate and the enzyme synthesized product had identical chromatographic characteristics on high pressure liquid chromatography. Minoxidil sulfate, which yields minoxidil when treated with sulfatase, was slowly hydrolyzed in water. Several N-oxides of other heterocycles, including several other pyrimidines, triazines and imidazoles, were also substrates for this sulfotransferase.
Animals • Biotransformation • Liver • Male • Minoxidil • Pyrimidines • Rats • Rats, Inbred Strains • Sulfurtransferases • enzymology* • metabolism*