Publications [#180939] of G. Allan Johnson
- P Pandit, Y Qi, J Story, KF King, GA Johnson, Multishot PROPELLER for high-field preclinical MRI.,
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, vol. 64 no. 1
pp. 47-53, ISSN 1522-2594 [doi]
(last updated on 2013/05/16)
With the development of numerous mouse models of cancer, there is a tremendous need for an appropriate imaging technique to study the disease evolution. High-field T(2)-weighted imaging using PROPELLER (Periodically Rotated Overlapping ParallEL Lines with Enhanced Reconstruction) MRI meets this need. The two-shot PROPELLER technique presented here provides (a) high spatial resolution, (b) high contrast resolution, and (c) rapid and noninvasive imaging, which enables high-throughput, longitudinal studies in free-breathing mice. Unique data collection and reconstruction makes this method robust against motion artifacts. The two-shot modification introduced here retains more high-frequency information and provides higher signal-to-noise ratio than conventional single-shot PROPELLER, making this sequence feasible at high fields, where signal loss is rapid. Results are shown in a liver metastases model to demonstrate the utility of this technique in one of the more challenging regions of the mouse, which is the abdomen.
Animals • Disease Models, Animal • Female • Image Processing, Computer-Assisted • Liver Neoplasms, Experimental • Magnetic Resonance Imaging • Mice • Mice, Inbred C57BL • Radiography, Abdominal • diagnosis • methods*