Publications [#60914] of George A. Truskey

Papers Published

1. Sharkawy, A. Adam and Klitzman, Bruce and Truskey, George A. and Reichert, W. Monty, Engineering the tissue which encapsulates subcutaneous implants. I. Diffusion properties, Journal of Biomedical Materials Research, vol. 37 no. 3 (1997), pp. 401 - 412 [(SICI)1097-4636(19971205)37:3<401::AID-JBM11>3.3.CO;2-X]
   (last updated on 2007/04/12)

   Abstract:
   Porous and nonporous polyvinyl alcohol (PVA) and stainless steel cage specimens were implanted in the subcutis of rats to elicit a range of capsular wound-healing tissues and to analyze small analyte transport through the tissue which encapsulates implants. The fibrous capsule forming around a subcutaneously implanted smooth-surface sensor imposes a significant diffusion barrier to small analytes, thus increasing the lag time of the sensor by as much as threefold. A sensor with a porous surface which allows tissue ingrowth may be more responsive to blood analyte fluctuations as a result of its a more vascular and less fibrous encapsulation tissue.

   Keywords:
   Polyvinyl alcohols;Stainless steel;Biosensors;Diffusion in solids;Tissue;Porous materials;Volume fraction;Physiological models;Encapsulation;