| Publications [#113099] of Harold P. Erickson
Papers Published
- DL Settles, RA Cihak, HP Erickson, Tenascin-C expression in dystrophin-related muscular dystrophy.,
Muscle & nerve, UNITED STATES, vol. 19 no. 2
(February, 1996),
pp. 147-54, ISSN 0148-639X
(last updated on 2009/02/12)
Abstract: The mdx mouse has a mutated dystrophin gene and is used as a model for the study of Duchenne muscular dystrophy (DMD). We investigated whether regenerating mdx skeletal muscle contains the extracellular matrix protein tenascin-C (TN-C), which is expressed in wound healing and nerve regeneration. Prior to the initiation of muscle degeneration, both normal and mdx mice displayed similar weak staining for TN-C in skeletal muscle, but by 3 weeks of age the mice differed substantially. TN-C was undetectable in normal muscle except at the myotendinous junction, while in dystrophic muscle, TN-C was prominent in degenerating/regenerating areas, but absent from undegenerated muscle. With increasing age, TN-C staining declined around stable regenerated mdx myofibers. TN-C was also observed in muscle from dogs with muscular dystrophy and in human boys with DMD. Therefore, in dystrophic muscle, TN-C expression may be stimulated by the degenerative process and remain upregulated unless the tissue undergoes successful regeneration.
Keywords: Animals • Blotting, Western • Dogs • Dystrophin • Humans • Immunohistochemistry • Mice • Mice, Inbred C57BL • Muscular Dystrophy, Animal • Nerve Regeneration* • Tenascin • Wound Healing* • analysis* • metabolism*
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